• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of toxicological sciences >Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA)
【24h】

Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA)

机译：改良鼠局部淋巴结试验（LLNA）的Bardoxolone甲基的免疫抑制潜力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

2-Cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid methyl ester (CDDO-Me; bardoxolone methyl) is one of the synthetic oleanane triterpenoids (SOs). It is known that it is the strongest Nrf2/ARE signaling inducer of SOs and slightly inhibits immune response. Little was known about the immunomodulatory action of CDDO-Me in vivo. We assessed its immunosuppressive potential by using the modified mouse lymph node assay (LLNA) including immunosuppression-related gene expression analysis. In the modified LLNA, CDDO-Me showed a significant decrease in lymph node weight and changes in expressions of the immunosuppression-related genes, Zfp459 and Fmo2. It has been already reported that a decrease in lymph node weight was induced by several types of immunosuppressive chemicals such as calcineurin inhibitors, antimetabolites, steroids, and alkylators. In addition, changes in Zfp459 and Fmo2 expression was reported in response after only treatment of antimetabolites. From these results, CDDOMe is considered to have an immunosuppressive action and similar mechanism to antimetabolites.
机译：2-Cyano-3、12-dioxooleana-1、9-dien-28-乙酸甲酯（CDDO-Me; bardoxolone甲基）是合成的齐墩果烷三萜类化合物（SOs）之一。众所周知，它是SOs最强的Nrf2 / ARE信号传导诱导剂，可轻微抑制免疫反应。关于CDDO-Me在体内的免疫调节作用知之甚少。我们通过使用改良的小鼠淋巴结试验（LLNA）（包括免疫抑制相关基因表达分析）评估了其免疫抑制潜力。在改良的LLNA中，CDDO-Me显着降低了淋巴结重量，并降低了免疫抑制相关基因Zfp459和Fmo2的表达。已经报道过，淋巴结重量的减少是由几种类型的免疫抑制化学物质引起的，例如钙调神经磷酸酶抑制剂，抗代谢物，类固醇和烷化剂。另外，据报道仅在抗代谢物治疗后Zfp459和Fmo2表达的变化。根据这些结果，CDDOMe被认为具有免疫抑制作用，并且与抗代谢物具有相似的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号