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首页> 外文期刊>The Journal of toxicological sciences >Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats
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Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats

机译：全氟十一烷酸在大鼠中的重复剂量和生殖/发育毒性

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摘要

Perfluoroalkyl acids (PFAAs) are environmental contaminants that have received attention because of their possible effects on wildlife and human health. In order to obtain initial risk information on the toxicity of perfluoroundecanoic acid (PFUA), we conducted a combined repeated dose toxicty study with the reproduction/developmental toxicity screening test (OECD test guideline 422). PFUA was administered by gavage to rats at 0 (vehicle: corn oil), 0.1, 0.3 or 1.0 mg/kg/day. At 1.0 mg/kg/day, body weight gain was inhibited in both sexes, and there was a decrease in fibrinogen in both sexes and shortening of the activated partial thromboplastin time in males. An increase in blood urea nitrogen and a decrease in total protein in both sexes and increases in alkaline phosphatase and alanine transaminase and a decrease in albumin in males were observed at 1.0 mg/kg/day. Liver weight was increased in males at 0.3 mg/kg/day and above and in females at 1.0 mg/kg/day, and this change was observed after a recovery period. In both sexes, centrilobular hypertrophy of hepatocytes was observed at 0.3 mg/kg/day and above and focal necrosis was observed at 1.0 mg/kg/day. In reproductive/developmental toxicity, body weight of pups at birth was lowered and body weight gain at 4 days after birth was inhibited at 1.0 mg/kg/day, while no dose-related changes were found in the other parameters. Based on these findings, the no observed adverse effect levels (NOAELs) for the repeated dose and reproductive/developmental toxicity were considered to be 0.1 mg/kg/day and 0.3 mg/kg/day, respectively.
机译：全氟烷基酸（PFAAs）是环境污染物，由于其可能影响野生生物和人类健康而受到关注。为了获得有关全氟十一烷酸（PFUA）毒性的初步风险信息，我们进行了重复剂量毒性研究与生殖/发育毒性筛选试验（OECD试验准则422）的组合。通过管饲法以0（车辆：玉米油），0.1、0.3或1.0 mg / kg /天的剂量向大鼠施用PFUA。在1.0 mg / kg / day时，男女的体重增加均受到抑制，而男女的纤维蛋白原减少，男性的活化部分凝血活酶时间缩短。在1.0 mg / kg /天时，男性的血尿素氮增加，总蛋白减少，碱性磷酸酶和丙氨酸转氨酶增加，白蛋白减少。雄性肝的体重在0.3 mg / kg /天及以上的情况下增加，而雌性在1.0 mg / kg /天的情况下增加，并且在恢复期后观察到这种变化。在男女中，均以0.3 mg / kg /天及以上的剂量观察到肝细胞的小叶肥大，并以1.0 mg / kg /天的剂量观察到局灶性坏死。在生殖/发育毒性方面，幼崽的体重降低了，出生后4天的体重增加被抑制为1.0 mg / kg / day，而其他参数没有发现剂量相关的变化。根据这些发现，重复剂量和生殖/发育毒性的未观察到的不良反应水平（NOAEL）分别为0.1 mg / kg /天和0.3 mg / kg /天。

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