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首页> 外文期刊>The Journal of toxicological sciences >Positive and negative ions by air purifier have no effects on embryo-fetal development in rats
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Positive and negative ions by air purifier have no effects on embryo-fetal development in rats

机译：空气净化器的正离子和负离子对大鼠胚胎胎儿发育没有影响

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Air purifiers, which release positive and negative ions generated by an electric discharge into the air, have been widely used in common households. In this study, the developmental toxicity potential of the ionized air containing positive and negative ions was evaluated in SD rats [Crl:CD(SD)] following whole-body inhalation to obtain preliminary information for the definitive study. Two groups of 10 pregnant female rats were exposed to the ionized air at concentrations of 0 and 7, 000, 000 ions/cm3 for 6 hr per day from Days 6 to 19 of gestation. All dams underwent a cesarean section on Day 20 of gestation and their fetuses were examined externally, viscerally, and skeletally for morphological changes. The ionized air had no effects on dams in terms of clinical signs, body weight, food consumption, gravid uterine weights, corrected body weight by gravid uterine weight, or necropsy findings. In addition, there were no effects on the maintenance of pregnancy, including abortion or premature delivery. No exposure-related changes were detected in the number of corpora lutea, implantations, dead embryos, or live fetuses, implantation loss, live fetal weights, sex ratio, or placental weight or features. Fetal examination revealed no external, visceral, or skeletal anomalies or variations caused by the ionized air, nor were there any changes in degree of ossification. Although this study did not fully adhere to the current guidelines because of a smaller number of animals per group, it was suggested that the ionized air has no maternal toxicity or embryo-fetal toxicity in rats.
机译：空气净化器将放电产生的正离子和负离子释放到空气中，已在普通家庭中广泛使用。在这项研究中，通过全身吸入后，对SD大鼠[Crl：CD（SD）]评估了包含正离子和负离子的电离空气的发育毒性潜力，从而为确定的研究提供了初步信息。从妊娠的第6天到第19天，每天将2组的10只怀孕的雌性大鼠每天以0和7、000、000离子/ cm3的浓度暴露于电离空气中6小时。在妊娠的第20天对所有大坝进行剖宫产，并从外部，内脏和骨骼检查胎儿的形态变化。电离空气对临床症状，体重，食物消耗，妊娠子宫重量，经妊娠子宫重量校正后的体重或尸检结果没有影响。此外，对维持妊娠没有影响，包括流产或早产。未检测到黄体数量，着床，死胚或活胎儿，着床损失，活胎儿重量，性别比或胎盘重量或特征方面与暴露相关的变化。胎儿检查没有发现由电离空气引起的外部，内脏或骨骼异常或变化，骨化程度也没有任何变化。尽管由于每组动物数量较少，该研究并未完全遵守当前的指导原则，但有人提出，电离空气对大鼠没有母体毒性或胚胎-胎儿毒性。

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