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首页> 外文期刊>The Journal of toxicological sciences >Thirteen-week oral toxicity of para- and ortho- chloronitrobenzene in rats and mice.
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Thirteen-week oral toxicity of para- and ortho- chloronitrobenzene in rats and mice.

机译：对和邻氯硝基苯对大鼠和小鼠的十三周口服毒性。

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Para- and ortho-chloronitrobenzene (p- and o-CNB) were compared for subchronic toxicity by feeding F344 rats and BDF(1) mice of both sexes p-CNB-or o-CNB-containing diets at 5 different concentrations for 13 weeks. The two isomers induced hematotoxicity and hepatotoxicity of different toxic potencies. p-CNB produced an anemic sign of external appearance in rats and mice, while o-CNB did not. Significant increases in the incidences of increased erythropoiesis in the bone marrow and increased extramedullary hematopoiesis in the spleen and liver, and in serum total bilirubin in rats and mice appeared at lower dose levels of p-CNB than o-CNB. A significant increase in serum ALT activity appeared at lower dose levels of o-CNB than p-CNB, together with appearance of both necrosis and hydropic degeneration of hepatocytes only in the o-CNB-fed rats and nuclear enlargement with atypia of hepatocytes only in the o-CNB-fed mice. BMDL(10)s of p- and o-CNB for the hematotoxic endpoint, substitutes for NOAELs, were 0.177 mg/kg/day and 1.03 mg/kg/day for the rats, respectively. For the mice, the NOAELs of p-and o-CNB for the hematotoxic endpoint were 10.5 mg/kg/day and 10.4 mg/kg/day, respectively. A NOEL of o-CNB for the hepatotoxic endpoint resulted in 13.8 mg/kg/day for the rats and 12.2 mg/kg/day for the mice. These results suggest that p-CNB is a more potent hematotoxicant than o-CNB, whereas o-CNB is a more potent hepatotoxicant than p-CNB, and that the rat hematopoietic system is more susceptible to p-CNB than the mouse hematopoietic system.
机译：比较了对-和邻-氯硝基苯（对-和邻-CNB）亚慢性毒性，方法是分别喂食含5种不同浓度的含p-CNB或o-CNB的雌性F344大鼠和BDF（1）小鼠13周。这两种异构体可引起血液毒性和不同毒性作用的肝毒性。 p-CNB在大鼠和小鼠体内产生贫血迹象，而o-CNB则没有。 p-CNB的剂量水平低于o-CNB，在大鼠和小鼠中，骨髓中的红细胞生成增加和脾脏和肝脏中的髓外造血活动的发生率显着增加，并且血清总胆红素的出现率更高。在o-CNB剂量低于p-CNB的情况下，血清ALT活性显着增加，并且仅在o-CNB喂养的大鼠中出现肝细胞坏死和水变性，并且仅在p-CNB时才出现肝细胞异型性核扩大。 o-CNB喂养的小鼠。对大鼠而言，p-和o-CNB的BMDL（10）取代NOAEL的血毒性终点分别为0.177 mg / kg /天和1.03 mg / kg /天。对于小鼠，p-和o-CNB的血液毒性终点的NOAEL分别为10.5 mg / kg /天和10.4 mg / kg /天。肝毒性终点的o-CNB NOEL对大鼠而言为13.8 mg / kg /天，对小鼠而言为12.2 mg / kg /天。这些结果表明，p-CNB比o-CNB有更强的血液毒性，而o-CNB比p-CNB有更强的肝毒性，并且大鼠的造血系统比小鼠的造血系统对p-CNB更敏感。

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