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首页> 外文期刊>The Journal of toxicological sciences >Venlafaxine ingestion is associated with rhabdomyolysis in adults: a case series.
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Venlafaxine ingestion is associated with rhabdomyolysis in adults: a case series.

机译：摄入文拉法辛与成人横纹肌溶解有关：一个病例系列。

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摘要

Rhabdomyolysis has been reported after venlafaxine ingestion. We wished to characterize the prevalence of this adverse effect in a realistic clinical setting. Therefore, a retrospective casenote review was performed, including 235 patients admitted to the Royal Infirmary of Edinburgh due to venlafaxine overdose between January 2000 and June 2006. Seizures occurred in 8.9% of the study population. Patients who suffered seizures had ingested larger quantities of venlafaxine than those who did not develop seizures; median (interquartile range) 2800 mg (2006-4350 mg) versus 1500 mg (900-2700 mg, p = 0.001). Raised CK values were more prevalent in those with seizures than those without seizures (61.1% versus 25.7% respectively, p = 0.004). Nonetheless, a positive correlation was found between the quantity of venlafaxine ingested and CK across the whole group (rho = 0.201, 95% confidence interval 0.045-0.347), and in patients who had not developed seizures (rho = 0.174, 95% confidence interval 0.009-0.331). Venlafaxine overdose is associated with a high prevalence of acute muscle injury, both in patients who develop seizures and in those who do not. The clinical significance of this association merits further consideration.
机译：服用文拉法辛后已有横纹肌溶解的报道。我们希望在现实的临床环境中表征这种不良反应的普遍程度。因此，进行了回顾性病例回顾，包括2000年1月至2006年6月之间因文拉法辛过量而入爱丁堡皇家医院收治的235例患者。研究人群中有8.9％发生癫痫发作。癫痫发作患者摄入的文拉法辛比未发作的患者摄入更多。中位数（四分位间距）2800 mg（2006-4350 mg）与1500 mg（900-2700 mg，p = 0.001）。癫痫发作患者的CK升高值高于无癫痫发作的患者（分别为61.1％和25.7％，p = 0.004）。但是，在整个组中，文拉法辛的摄入量与CK呈正相关（rho = 0.201，95％置信区间0.045-0.347），而未发生癫痫的患者（rho = 0.174，95％置信区间） 0.009-0.331）。无论是发生癫痫发作的患者还是没有发作的患者，文拉法辛过量都与急性肌肉损伤的高发生率相关。这种关联的临床意义值得进一步考虑。

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