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首页> 外文期刊>The Journal of toxicological sciences >Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish.
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Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish.

机译：dinophysistoxin-3的代谢转化为dinophysistoxin-1，由于食用被污染贝类的O-酰基衍生物dinophysistoxins而引起人中毒。

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This paper describes for the first time a massive intoxication episode due to consumption of shellfish contaminated with 7-O-acyl-derivative dinophysistoxin-1, named Dinophysistoxin-3 (DTX-3). 7-O-acyl-derivative dinophysistoxin-1, a compound recently described in the literature, was found in shellfish samples collected in the Chilean Patagonia fjords. This compound does not inhibit Protein Phosphatases and also does not elicit the symptoms described for Diarrheic Shellfish Poisoning (DSP). The data showed here, give evidence of metabolic transformation of 7-O-acyl-derivative dinophysistoxin-1 (DTX-3) into Dinophysistoxin-1 (DTX-1, Methyl-Okadaic acid) in intoxicated patients. This metabolic transformation is responsible for the diarrheic symptoms and the intoxication syndrome showed by patients that consumed contaminated shellfish, which showed only the presence of 7-O-acyl-derivative dinophysistoxin-1. Patients fecal bacterial analysis for the presence of enteropathogens was negative and the mouse bioassay for DSP, performed as described for regulatory testing, was also negative. The HPLC-FLD and HPLC-MS analysis showed only the presence of DTX-3 as the only compound associated to DSP toxins in the contaminated shellfish samples. No other DSP toxins were found in the shellfish sample extracts. However, the patient fecal samples showed DTX-1 as the only DSP toxins detected in fecal. Moreover, the patient fecal samples did not show DTX-3. Since 7-O-acyl-derivative dinophysistoxin-1 (DTX-3) was the only compound associated to DSP toxins detected in the shellfish samples, an explanation for the diarrheic symptoms in the intoxicated patients would be the metabolic transformation of DTX-3 into DTX-1. This transformation should occur in the stomach of the poisoned patients after consuming 7-O-acyl-derivatives dinophysistoxin-1 (DTX-3) contaminated bivalves.
机译：本文首次描述了由于食用被7-O-酰基衍生物dinophysistoxin-1（称为Dinophysistoxin-3（DTX-3））污染的贝类而引起的大规模中毒事件。在智利巴塔哥尼亚峡湾采集的贝类样品中发现了最近在文献中描述的化合物7-O-酰基衍生物dinophysistoxin-1。该化合物不抑制蛋白磷酸酶，也不会引起腹泻性贝类中毒（DSP）的症状。此处显示的数据为中毒患者的7-O-酰基衍生物dinophysistoxin-1（DTX-3）代谢转化为Dinophysistoxin-1（DTX-1，甲基-冈田酸）提供了证据。这种新陈代谢的转变是由食用受污染的贝类的患者表现出的腹泻症状和中毒综合症，仅显示7-O-酰基衍生的dinophysistoxin-1的存在。患者粪便细菌分析中肠病原体的存在为阴性，按法规测试所述进行的DSP小鼠生物测定也为阴性。 HPLC-FLD和HPLC-MS分析表明，在受污染的贝类样品中，只有DTX-3作为与DSP毒素相关的唯一化合物存在。在贝类样品提取物中未发现其他DSP毒素。但是，患者粪便样品显示DTX-1是粪便中唯一检测到的DSP毒素。此外，患者粪便样本未显示DTX-3。由于7-O-酰基衍生的dinophysistoxin-1（DTX-3）是与贝类样品中检测到的DSP毒素相关的唯一化合物，因此，对中毒患者腹泻症状的解释是DTX-3代谢为DTX-1。食用受7-O-酰基衍生物dinophysistoxin-1（DTX-3）污染的双壳类动物后，这种转化应发生在中毒患者的胃中。

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