Unexpected sudden deaths of F344 rats in long-term toxicity studies: relationship between sudden deaths and stomach tube material or feed type

Takumi Ohishi; Masahiro Mochizuki; Tomonori Enami; Kazushi Okazaki; Shuzo Okazaki

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Unexpected sudden deaths of F344 rats in long-term toxicity studies: relationship between sudden deaths and stomach tube material or feed type

机译：长期毒性研究中F344大鼠的意外猝死：猝死与胃管材料或饲料类型之间的关系

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摘要

Sudden deaths of F344 rats (F344/Du Crj (Fischer)) have occurred frequently in the late stage of carcinogenicity studies using stomach tubes. To reduce the sudden deaths, the incidence of sudden deaths was compared in the control groups from 104-week carcinogenicity studies using two different stomach tubes (metal and Teflon) and feeds (pellet and powder). The results indicate that replacing metal tubes with Teflon tubes from the first administration or after week 41 of administration was not effective in reducing the sudden deaths. On the other hand, sudden deaths did not occur at all after changing the feed from pellets to powder after week 44 or 79 of administration. In addition, although decreased body weight and retention of feed in the oral, pharyngeal and laryngeal cavities were observed in the animals that died suddenly, there were no abnormalities in histopathological examination. Therefore, it is suggested that changing the feed from pellets to powder should be effective in reducing the sudden deaths of F344 rats in long-term oral gavage studies or carcinogenicity studies.

机译：F344大鼠（F344 / Du Crj（Fischer））的突然死亡在使用胃管进行致癌性研究的后期阶段屡见不鲜。为了减少猝死，在104个星期的致癌性研究中，比较了对照组的猝死发生率，使用了两种不同的胃管（金属和铁氟龙）和饲料（丸剂和粉剂）。结果表明，从第一次给药开始或在给药第41周后，用特氟龙管替换金属管对减少猝死无效。另一方面，在给药第44或79周后将饲料从颗粒剂改为粉剂后，根本没有发生猝死。另外，尽管在突然死亡的动物中观察到体重降低和饲料在口腔，咽和喉腔中的滞留，但是组织病理学检查没有异常。因此，建议在长期口服管饲研究或致癌性研究中，将饲料从颗粒状改为粉状可有效减少F344大鼠的突然死亡。

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《The Journal of toxicological sciences》 |2008年第4期|共5页
作者
Takumi Ohishi; Masahiro Mochizuki; Tomonori Enami; Kazushi Okazaki; Shuzo Okazaki;
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正文语种 eng
中图分类药学;
关键词
Death; Sudden; Stomach; Rattus norvegicus; week; 猝死; 胃;

机译：Death;Sudden;Stomach;Rattus norvegicus;week;猝死;胃;

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1. Unexpected sudden deaths of F344 rats in long-term toxicity studies: relationship between sudden deaths and stomach tube material or feed type [J] . Takumi Ohishi, Masahiro Mochizuki, Tomonori Enami, The Journal of toxicological sciences . 2008,第4期

机译：长期毒性研究中F344大鼠的意外猝死：猝死与胃管材料或饲料类型之间的关系
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机译：心肌梗死和心源性猝死的发病 - 社区猝死和心肌梗死的病理学和回顾性研究。

Unexpected sudden deaths of F344 rats in long-term toxicity studies: relationship between sudden deaths and stomach tube material or feed type

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