Anidulafungin and Fluconazole for Candidiasis

Nir-Paz R.; Moses A.E.

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Anidulafungin and Fluconazole for Candidiasis

机译：阿尼芬净和氟康唑治疗念珠菌病

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to the editor: The study of anidulafungin as compared with fluconazole for invasive candidia-sis by Reboli et al. (June 14 issue) shows the challenges involved in the design and reporting of noninferiority trials. First, the dose of fluconazole may have been inadequate. Second, no justification is provided for the conspicuously large prestated margin of noninferiority used in this trial, even though justification is recommended. This prestated margin of noninferiority implies that a difference in treatment effect of less than#

机译：致编辑：Reboli等人研究了阿尼芬净与氟康唑对侵袭性念珠菌病的关系。（6月14日发行）显示了非劣效性临床试验的设计和报告所面临的挑战。首先，氟康唑的剂量可能不足。其次，即使推荐使用正当理由，也没有为这项试验中明显使用的较大的自卑感提供正当理由。预先设定的非自卑程度意味着治疗效果差异小于＃

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来源
《The New England journal of medicine》 |2007年第13期|共2页
作者
Nir-Paz R.; Moses A.E.;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Fluconazole; Candidiasis; Reporting; First; therapeutic aspects; 氟康唑; 念珠菌病;

机译：Fluconazole;Candidiasis;Reporting;First;therapeutic aspects;氟康唑;念珠菌病;

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1. Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis: Support for the 2009 IDSA treatment guidelines for candidiasis [J] . Daniel H Kett, Andrew F Shorr, Annette C Reboli, Critical care : . 2011,第5期

机译：重度念珠菌血症和其他形式的侵袭性念珠菌病患者中阿尼芬净与氟康唑的比较：支持2009 IDSA念珠菌治疗指南
2. Cost‐effectiveness analysis of anidulafungin vs fluconazole for the treatment of invasive candidiasis ( IC IC ) in Turkey [J] . Neoh Chin Fen, Senol Esin, Kara Ates, Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases . 2017,第11期

机译：Anidulafungin VS氟康唑治疗土耳其侵袭性念珠菌（IC）的成本效果分析
3. Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis [J] . WiederholdN.P., NajvarL.K., BocanegraR., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2012,第2期

机译：侵袭性念珠菌病中性粒细胞减少和非中性粒细胞减少模型中阿尼芬净和氟康唑的体内活性比较
4. ANIDULAFUNGIN AND ITS PRIMARY BIOTRANSFORMATION PRODUCT - CHALLENGES IN AN LC-MS/MS BIOANALYTICAL ASSAY [C] . Tanja Alebic-Kolbah, Michael Modesitt American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：Anidulafungin及其主要生物转化产品 - LC-MS / MS生物分析测定中的挑战
5. Development & evaluation of a topical dosage form for the delivery of fluconazole for treating vulvovaginal candidiasis. [D] . Elkeeb, Rania M. 2005

机译：开发和评估用于治疗氟尿嘧啶念珠菌病的氟康唑局部给药剂型。
6. Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis: Support for the 2009 IDSA treatment guidelines for candidiasis [O] . Daniel H Kett, Andrew F Shorr, Annette C Reboli, 2011

机译：重度念珠菌血症和其他形式的侵袭性念珠菌病患者中阿尼芬净与氟康唑的比较：支持2009 IDSA念珠菌治疗指南
7. Anidulafungin compared with fluconazole in severely ill patients with candidemia and other forms of invasive candidiasis: Support for the 2009 IDSA treatment guidelines for candidiasis [O] . Daniel H Kett, Andrew F Shorr, Annette C Reboli, 2011

机译：重度念珠菌血症和其他形式的侵袭性念珠菌病患者中阿尼芬净与氟康唑的比较：支持2009 IDSA念珠菌治疗指南

Anidulafungin and Fluconazole for Candidiasis

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