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首页> 外文期刊>The New England journal of medicine >Acetaminophen, aspirin, and chronic renal failure.
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Acetaminophen, aspirin, and chronic renal failure.

机译：对乙酰氨基酚，阿司匹林和慢性肾功能衰竭。

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BACKGROUND: Several epidemiologic studies have demonstrated an association between heavy consumption of nonnarcotic analgesics and the occurrence of chronic renal failure, but it is unclear which is the cause and which is the effect METHODS: In a nationwide, population-based, case-control study of early-stage chronic renal failure in Sweden, face-to-face interviews were conducted with 926 patients with newly diagnosed renal failure and 998 control subjects, of whom 918 and 980, respectively, had complete data. We used logistic-regression models to estimate the relative risks of disease-specific types of chronic renal failure associated with the use of various analgesics RESULTS: Aspirin and acetaminophen were used regularly by 37 percent and 25 percent, respectively, of the patients with renal failure and by 19 percent and 12 percent, respectively, of the controls. Regular use of either drug in the absence of the other was associated with an increase by a factor of 2.5 in the risk of chronic renal failure from any cause. The relative risks rose with increasing cumulative lifetime doses, rose more consistently with acetaminophen use than with aspirin use, and were increased for most disease-specific types of chronic renal failure. When we disregarded the recent use of analgesics, which could have occurred in response to antecedents of renal disease, the associations were only slightly attenuated CONCLUSIONS: Our results are consistent with the existence of exacerbating effects of acetaminophen and aspirin on chronic renal failure. However, we cannot rule out the possibility of bias due to the triggering of analgesic consumption by predisposing conditions.
机译：背景：几项流行病学研究表明，大量服用非麻醉性镇痛药与慢性肾功能衰竭的发生之间存在关联，但目前尚不清楚是哪种原因和效果。方法：在全国范围内，以人群为基础的病例对照研究在瑞典的早期慢性肾衰竭中，对926名新诊断的肾衰竭患者和998名对照受试者进行了面对面访谈，其中分别有918名和980名拥有完整的数据。我们使用逻辑回归模型来估计与各种镇痛药有关的特定疾病类型的慢性肾衰竭的相对风险。结果：阿司匹林和对乙酰氨基酚分别有37％和25％的肾衰竭患者经常使用分别占对照的19％和12％。在不存在另一种药物的情况下定期使用任何一种药物，由于任何原因引起的慢性肾衰竭的风险增加2.5倍。相对风险随着累积终生剂量的增加而上升，对乙酰氨基酚的使用比阿司匹林的使用更一致，并且对于大多数特定疾病类型的慢性肾功能衰竭而言，相对风险增加。当我们不考虑最近使用的止痛药时（可能是对肾脏疾病的前体反应而发生的），其相关性仅略有减弱。结论：我们的结果与对乙酰氨基酚和阿司匹林对慢性肾功能衰竭的恶化作用存在一致。但是，我们不能排除因预先设定条件而触发止痛药消费而产生偏差的可能性。

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