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首页> 外文期刊>The New England journal of medicine >Evaluation of impermeable covers for bedding in patients with allergic rhinitis.
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Evaluation of impermeable covers for bedding in patients with allergic rhinitis.

机译：过敏性鼻炎患者不可渗透的床上用品评估。

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BACKGROUND: Encasing bedding in impermeable covers reduces exposure to house-dust mites, but the clinical benefit of this intervention as part of mite-avoidance measures for patients with allergic rhinitis is not known. We performed a multicenter, randomized, placebo-controlled trial of one year of use of impermeable bedding covers in the bedrooms of patients with rhinitis who were sensitized to house-dust mites to determine the effects on the signs and symptoms of disease. METHODS: Three participating university medical centers enrolled 279 patients with allergic rhinitis who were randomly assigned to receive impermeable or non-impermeable (control) covers for their mattress, pillow, and duvet or blanket. At the start of the study, all participants received information on general allergen-avoidance measures. The severity of rhinitis was measured on a rhinitis-specific visual-analogue scale and by means of a daily symptom score and nasal allergen provocation testing. We also measured the concentrationsof Dermatophagoides pteronyssinus (Der p1) and D. farinae (Der f1) in dust from patients' mattresses, bedroom floors, and living-room floors at base line and after 12 months as a measure of the efficacy of the intervention. RESULTS: A total of 232 patients completed the study. There was a significant reduction in Der p1 and Der f1 concentrations in the mattresses of the impermeable-cover group, whereas there was no significant reduction in the control group. However, there was no significant effect on the clinical outcome measures. Analyses of subgroups defined according to age, level of exposure, type and severity of sensitization, or characteristics of the patient's home had similar results. CONCLUSIONS: Mite-proof bedding covers, as part of a structured allergy-control program, reduced the level of exposure to mite allergens. Despite the success of the intervention, this single avoidance measure did not lead to a significant improvement of clinical symptoms in patients with allergic rhinitis.
机译：背景：将被褥包裹在不透水的覆盖物中可减少室内尘螨的暴露，但是这种干预作为过敏性鼻炎患者避免螨虫措施的一部分的临床益处尚不明确。我们进行了一项多中心，随机，安慰剂对照试验，该试验在对房屋尘螨敏感的鼻炎患者的卧室中使用不透水床上用品，为期一年，以确定对疾病征兆和症状的影响。方法：三个参与研究的大学医学中心招募了279名过敏性鼻炎患者，他们被随机分配接受不可渗透或不可渗透（对照）的床垫，枕头，羽绒被或毯子覆盖物。在研究开始时，所有参与者都获得了有关常规避免过敏原措施的信息。鼻炎的严重程度通过特定于鼻炎的视觉模拟量表并通过每日症状评分和鼻过敏原激发试验进行测量。我们还测量了基线和12个月后患者床垫，卧室地板和客厅地板上灰尘中粉尘螨（Der pophonyssinus（Der p1）和粉虱D. farinae（Der f1）的浓度，作为干预效果的量度。结果：总共232例患者完成了研究。不可渗透覆盖物组的床垫中Der p1和Der f1浓度显着降低，而对照组则没有显着降低。但是，对临床结果指标没有显着影响。根据年龄，暴露水平，致敏类型和严重程度或患者家庭特征定义的亚组分析具有相似的结果。结论：作为结构化过敏控制程序的一部分，防螨床上用品可降低螨过敏原的暴露水平。尽管干预措施取得了成功，但这种单一的避免措施并未使过敏性鼻炎患者的临床症状得到明显改善。

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