The 2010 Nobel Prize in Physiology or Medicine: In vitro Fertilization (IVF): A Revolutionary Spark in Medicine, Biology and Genetics

Jaime Garcia-Heras

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The 2010 Nobel Prize in Physiology or Medicine: In vitro Fertilization (IVF): A Revolutionary Spark in Medicine, Biology and Genetics

机译：2010年诺贝尔生理学或医学奖：体外受精（IVF）：医学，生物学和遗传学的革命性火花

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The Nobel Assembly of the Karolinska Institute awardedthe 2010 Nobel Prize in Physiology or Medicine to Robert G.Edwards for his pioneering work on in vitro fertilization (IVF).This discovery allowed a novel treatment of infertility in womenand was the groundwork for many innovations in reproductivemedicine, medical genetics, and cell biology. Since 1978 IVF hasbeen very effective in infertile couples who did not have otheralternatives to conceive their own children. In the early 1990s, IVFopened the gateway to preimplantation genetic diagnosis (PGD),initially for couples at risk of having offspring with heritablediseases. Other genetic studies on IVF embryos highlighted thefrequent occurrence of chromosomal aneuploidies, and morerecently, DNA rearrangements associated with early pregnancylosses.

机译：卡罗林斯卡研究所的诺贝尔奖获得者罗伯特·G·爱德华兹（Robert G.Edwards）在体外受精（IVF）方面的开创性工作获得了2010年诺贝尔生理学或医学奖，这一发现为妇女的不育症提供了新颖的治疗方法，也是生殖医学许多创新的基础，医学遗传学和细胞生物学。自1978年以来，IVF在没有其他备选方案怀孕自己的孩子的不育夫妇中非常有效。在1990年代初期，IVF开启了植入前遗传学诊断（PGD）的大门，最初是为有遗传后代风险的夫妇提供的。有关IVF胚胎的其他遗传研究也强调了染色体非整倍性的频繁发生，以及最近与早孕相关的DNA重排。

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《The Journal of the Association of Genetic Technologists》 |2010年第4期|共4页
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Jaime Garcia-Heras;
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The 2010 Nobel Prize in Physiology or Medicine: In vitro Fertilization (IVF): A Revolutionary Spark in Medicine, Biology and Genetics

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