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首页> 外文期刊>The Lancet >Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
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Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics

机译：阿尔茨海默氏病是神经退行性疾病还是血管疾病？数据，教条和辩证法

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The cause of Alzheimer's disease (AD) is unknown. This gap in knowledge has created a stumbling block in the search for a genuinely effective treatment or cure for this dementia. This article summarises the arguments for a causal role for either amyloid deposition or cerebrovascular pathology as the primary trigger in the development of non-genetic AD. A bare-bones survey of the published research reveals no compelling evidence that amyloid deposition is neurotoxic in human beings or that it results in neurodegenerative changes involving synaptic, metabolic, or neuronal loss in human or transgenic-mouse brains. By contrast, the data supporting AD as a primary vascular disorder are more convincing. Findings suggesting a vascular cause of AD come from epidemiological, neuroimaging, pathological, pharmacotherapeutic, and clinical studies. The consensus of these studies indicates that chronic brain hypoperfusion is linked to AD risk factors, AD preclinical detection and pharmacotherapeutic action of AD symptoms.
机译：阿尔茨海默氏病（AD）的病因尚不清楚。知识上的鸿沟为寻找真正有效的治疗或治疗痴呆症提供了绊脚石。本文总结了淀粉样蛋白沉积或脑血管病理病因是非遗传性AD发生的主要触发因素的原因。一项对已发表研究的粗略调查显示，没有令人信服的证据表明淀粉样蛋白沉积对人类具有神经毒性，或导致人或转基因小鼠大脑中的突触，代谢或神经元丧失，从而导致神经退行性改变。相比之下，支持AD作为原发性血管疾病的数据更具说服力。提示AD的血管病因的发现来自流行病学，神经影像学，病理学，药物治疗和临床研究。这些研究的共识表明，慢性脑灌注不足与AD危险因素，AD临床前检测和AD症状的药物治疗作用有关。

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