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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Genetic factors associated with the absence of atherosclerosis in octogenarians.
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Genetic factors associated with the absence of atherosclerosis in octogenarians.

机译：遗传因素与八十岁以下人群中没有动脉粥样硬化有关。

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BACKGROUND: Atherosclerosis (ATS) is a common age-related disease of large arteries. The prevalence of older subjects with vascular successful aging (VaSA), defined as the absence of clinical symptoms and instrumental signs of ATS, is low in Western countries. The possible contribution of genetics to the VaSA phenomenon is not known. METHODS: We investigated the distribution of four genetic polymorphisms (angiotensin converting enzyme [ACE], methylenetetrahydrofolate reductase [MTHFR], apolipoprotein E [apo E], and paraoxonase [PON] genes) in 30 subjects with VaSA, 30 subjects with moderate carotid atherosclerosis (ATS group), and 161 controls with a negative history for cardiovascular disease. Clinical examination; ultrasonographic examination of carotid, vertebral, abdominal aortic, iliac, and femoral arteries; and electrocardiogram were performed. RESULTS: The frequency of PON 192 B allele was lower in VaSA patients (13%) compared with ATS patients (37%) and controls (46%) ( p =.06 and.006, respectively); B/B homozygotes were 27% in the ATS group, 12% in controls, and 0% in the VaSA group. The frequency of the MTHFR thermolable + allele was higher in VaSA (0.51) compared with ATS (0.39) and controls (0.40) (VaSA vs C, p =.006). No differences in the distribution of ACE I/D and apo E alleles emerged between the three groups. CONCLUSIONS: The low prevalence of the PON 192 B allele in the VaSA subjects suggests that this polymorphism might have an important role in VaSA, probably by hydrolyzing lipid peroxides and thus preventing low-density lipoprotein from undergoing the oxidative modification. This finding further supports the oxidative hypothesis of ATS.
机译：背景：动脉粥样硬化（ATS）是一种常见的与年龄相关的大动脉疾病。在西方国家，具有血管成功衰老（VaSA）的老年受试者的患病率低，VaSA的定义是缺乏ATS的临床症状和工具症状。遗传学对VaSA现象的可能贡献尚不清楚。方法：我们调查了30名VaSA患者，30名中度颈动脉粥样硬化患者的四种遗传多态性分布（血管紧张素转换酶[ACE]，亚甲基四氢叶酸还原酶[MTHFR]，载脂蛋白E [apo E]和对氧磷酶[PON]基因）。 （ATS组）和161例心血管疾病病史阴性的对照组。临床检查;颈，椎，腹主动脉，和股动脉的超声检查;并进行心电图检查。结果：VaSA患者中PON 192 B等位基因的频率（13％）低于ATS患者（37％）和对照组（46％）（分别为p = .06和.006）; ATS组的B / B纯合子为27％，对照组为12％，VaSA组为0％。与ATS（0.39）和对照（0.40）相比，VaSA（0.51）中MTHFR可热化+等位基因的频率更高（VaSA对C，p = .006）。三组之间的ACE I / D和apo E等位基因分布没有差异。结论：VaSA受试者中PON 192 B等位基因的低患病率表明，该多态性可能在VaSA中具有重要作用，可能是通过水解脂质过氧化物，从而防止低密度脂蛋白进行氧化修饰。这一发现进一步支持了ATS的氧化假设。

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