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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.
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Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.

机译：随着人类对分解代谢刺激的刺激，软骨细胞的基质金属蛋白酶13产量增加。

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Chondrocyte anabolic activity has been shown to decline with aging, but catabolic activity has received little attention. In this study, the effect of aging on the chondrocyte catabolic response was determined by stimulating isolated human chondrocytes with fibronectin fragments (FN-f) or interleukin-1beta and measuring matrix metalloproteinase-13 (MMP-13) production as a catabolic response. A significant age-related increase in chondrocyte MMP-13 production was noted. FN-f stimulation of MMP-13 expression was blocked using a nuclear factor kappa-B (NFkappaB) inhibitor suggesting a role for NFkappaB in this chondrocyte catabolic response. Chondrocyte production of the NFkappaB-regulated cytokine interleukin-1beta was also found to increase with donor age in unstimulated cells. These results demonstrate a significant age-related increase in chondrocyte catabolic responsiveness which could contribute to the development of osteoarthritis in older adults.
机译：软骨细胞的合成代谢活性已经显示出随着衰老而下降，但是分解代谢活性却很少受到关注。在这项研究中，通过用纤连蛋白片段（FN-f）或白介素1β刺激分离的人软骨细胞并测量基质金属蛋白酶13（MMP-13）的分解代谢来确定衰老对软骨细胞分解代谢反应的影响。注意到与年龄相关的软骨细胞MMP-13产量显着增加。使用核因子κB（NFkappaB）抑制剂阻断了FN-f刺激MMP-13表达，提示NFkappaB在该软骨细胞分解代谢反应中的作用。在未刺激的细胞中，NFkappaB调节的细胞因子白介素-1β的软骨细胞产量也随着供体年龄的增加而增加。这些结果表明，与年龄相关的软骨细胞分解代谢反应显着增加，这可能有助于老年人骨关节炎的发展。

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