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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Regaining lost youth: the controversial and colorful beginnings of hormone replacement therapy in aging.
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Regaining lost youth: the controversial and colorful beginnings of hormone replacement therapy in aging.

机译：重新失去年轻人：衰老中充满争议的多彩激素替代疗法的开端。

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摘要

The quest for regaining lost youth seems to have existed since the beginning of recorded history and has taken many forms. One strategy that began in earnest in the latter part of the 19th century and continues to have enormous momentum today is based on the notion that by replacing internally secreted substances, that is, hormones, that decline with age, the vitality and physical attributes associated with youth can be regained. Although the approach remains highly controversial as, for example, in "anti-aging medicine," it is no more controversial than it was many years ago when the work of three high profile investigators, Charles Eduoard Brown-Sequard, Eugen Steinach, and Serge Voronoff set the basis for using this strategy. In the case of all three individuals, the therapies they developed received widespread attention (including ridicule) in the popular press, were spread rapidly by practitioners of questionable training and ethical motivation, and finally and relatively quickly disappeared from common use. However, and ultimately more importantly, in the process of developing and promoting their therapies, these individuals made important contributions to the origins of endocrinology, the biology of sex, and establishment of hormone replacement therapy. It remains to be seen whether contemporary efforts using hormone replacement therapy to blunt and reverse aging have the same fate as their predecessors and make comparable important contributions to biology and medicine.
机译：自从有记录的历史开始以来，寻找失落的青年的努力似乎就已经存在，并且采取了多种形式。一种策略始于19世纪后期，并在今天一直保持着巨大的发展势头，其依据是这样一种观念，即通过替换随年龄而下降的内在分泌物质（即激素），与之相关的生命力和身体属性。青春可以恢复。尽管这种方法在“抗衰老医学”等方面仍然存在很大争议，但与三年前著名查尔斯·爱德华·布朗·塞奎德，尤金·史泰纳赫和谢尔格的三位知名研究人员的工作相比，该方法没有争议。 Voronoff为使用该策略奠定了基础。就这三个人而言，他们开发的疗法在大众媒体中得到了广泛的关注（包括嘲笑），受到具有可疑训练和道德动机的从业人员迅速传播，最后相对较快地从普遍使用中消失了。然而，并且最终更重要的是，在开发和推广其疗法的过程中，这些人对内分泌学的起源，性生物学和激素替代疗法的建立做出了重要贡献。当代使用激素替代疗法来钝化和逆转衰老的努力是否与他们的前辈一样命运，并在生物学和医学上做出可比的重要贡献，还有待观察。

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