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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults.
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A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults.

机译：对社区居住的老年人中的行动不便的地区进行了体积分析。

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BACKGROUND: In community-dwelling older adults, greater mobility impairment is associated with greater burden of diffuse brain structural abnormalities, such as higher white matter hyperintensities. This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities. METHODS: A random sample of 327 participants of the Cardiovascular Health Study (78.3 +/- 4.1 years old, 57% women) contributed brain magnetic resonance imaging (MRI) and mobility data. A brain imaging automated method measured gray matter volume in cerebellum, basal ganglia, and prefrontal and parietal cortex in both hemispheres. Gait speed was measured while walking 15 feet at usual pace. Standing balance was assessed by timing tandem stance. Associations between each region's volume and gait speed or balance were measured before and after adjustment for demographics, head size, cardiovascular risk factors, and 0-9 grading scores of white matter hyperintensities. RESULTS: Smaller left cerebellum and left prefrontal regions were associated with slower gait, independently of covariates and of white matter hyperintensities. Smaller right putamen, right posterior superior parietal cortex, and both left and right cerebellum were associated with balance difficulty, independently of covariates and white matter hyperintensities. CONCLUSIONS: Smaller gray matter volumes in regions crucial for motor control are associated with slower gait and poorer balance, and the association appears to be independent of other diffuse brain abnormalities such as white matter hyperintensities.
机译：背景：在居住社区的老年人中，更大的行动能力障碍与弥漫性脑结构异常（例如更高的白质高信号）负担更大。这项研究检查了与运动控制，步态和平衡有关的区域的灰质量之间的关联，以及这种关联是否独立于白质高信号的负担。方法：随机抽取327名心血管健康研究参与者（78.3 +/- 4.1岁，女性57％）作为样本，提供了脑磁共振成像（MRI）和活动性数据。一种脑成像自动方法可测量两个半球的小脑，基底神经节以及额叶和顶叶皮质的灰质体积。在以通常的速度行走15英尺时测量步态速度。站立平衡是通过时机串联评估的。在调整人口统计学，头部大小，心血管危险因素以及白质高信号的0-9评分之前和之后，测量每个区域的体积与步态速度或平衡之间的关联。结果：较小的左小脑和左前额叶区域与步伐较慢相关，独立于协变量和白质高信号。较小的右壳核，右后顶上皮层以及左右小脑都与平衡困难相关，而与协变量和白质高信号无关。结论：对于运动控制至关重要的区域较小的灰质体积与较慢的步态和较差的平衡有关，并且这种关联似乎与其他弥漫性脑部异常（例如白质高信号）无关。

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