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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of an ad libitum, high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women.
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Effects of an ad libitum, high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women.

机译：随意饮食，高碳水化合物饮食和有氧运动训练对老年男女的胰岛素作用和肌肉代谢的影响。

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BACKGROUND: Previous studies have demonstrated that aerobic exercise training and weight loss have independent effects on insulin-stimulated glucose disposal (ISGD). We hypothesized that ad libitum consumption of a high-carbohydrate diet would result in weight loss and improved ISGD, and that aerobic exercise training would facilitate greater improvements in ISGD compared with diet alone. METHODS: Older participants (13 women, 9 men; age = 66 +/- 1 year) with impaired glucose tolerance were randomly assigned to an ad libitum diet alone (18% fat, 19% protein, 63% carbohydrate) or this diet plus aerobic exercise training (4 d/wk, 45 min/d, 80% VO(2peak)) for 12 weeks. ISGD, abdominal fat distribution, muscle glycogen, and glycogen synthase activity were assessed pre- and postintervention. RESULTS: Consumption of the diet resulted in significant weight loss and an improvement in ISGD. Consumption of the diet plus exercise training also resulted in weight loss and increased ISGD, but results were not significantly different from those in the diet-alone group. Mean abdominal visceral and subcutaneous adipose tissue cross-sectional areas were smaller postintervention compared to baseline with no difference between groups. Exercise training and consumption of the diet increased muscle glycogen content (344.7 +/- 21.3 to 616.7 +/- 34.4 micromol.g(-1)) and decreased glycogen synthase activity (0.21 +/- 0.02 to 0.13 +/- 0.01) compared to the diet alone. CONCLUSIONS: These results demonstrate that consumption of an ad libitum, high-carbohydrate diet alone or in combination with aerobic exercise training results in weight loss and improved insulin sensitivity. Furthermore, exercise combined with this diet appears to limit additional increases in insulin sensitivity due to muscle glycogen supercompensation with a concomitant adaptive response of glycogen synthase.
机译：背景：以前的研究表明，有氧运动训练和减肥对胰岛素刺激的葡萄糖处置（ISGD）具有独立的影响。我们假设随意摄入高碳水化合物饮食将导致体重减轻和ISGD改善，而有氧运动训练与单纯饮食相比将促进ISGD的更大改善。方法：将糖耐量受损的年龄较大的参与者（13名女性，9名男性;年龄= 66 +/- 1岁）随机分配为随意饮食（18％脂肪，19％蛋白质，63％碳水化合物）或这种饮食加有氧运动训练（4 d / wk，45 min / d，80％VO（2peak））持续12周。干预前后评估ISGD，腹部脂肪分布，肌肉糖原和糖原合酶活性。结果：饮食饮食导致体重明显减轻，ISGD改善。饮食和运动训练的消耗也导致体重减轻和ISGD升高，但结果与单纯饮食组没有显着差异。与基线相比，干预后平均腹部内脏和皮下脂肪组织的横截面积较小，各组之间无差异。运动训练和饮食饮食相比增加了肌肉糖原含量（344.7 +/- 21.3至616.7 +/- 34.4 micromol.g（-1））和糖原合酶活性降低（0.21 +/- 0.02至0.13 +/- 0.01）单独饮食。结论：这些结果表明，单独食用高碳水化合物饮食或与有氧运动训练相结合可导致体重减轻和胰岛素敏感性提高。此外，与这种饮食相结合的运动似乎由于肌肉糖原超补偿以及糖原合酶的适应性反应而限制了胰岛素敏感性的进一步增加。

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