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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Low serum micronutrient concentrations predict frailty among older women living in the community.
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Low serum micronutrient concentrations predict frailty among older women living in the community.

机译：低血清微量营养素浓度预示着居住在社区中的老年妇女虚弱。

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BACKGROUND: Micronutrient deficiencies are common among older adults. We hypothesized that low serum micronutrient concentrations were predictive of frailty among older disabled women living in the community. METHODS: We studied 766 women, aged 65 and older, from the Women's Health and Aging Study I, a population-based study of moderately to severely disabled community-dwelling women in Baltimore, Maryland. Serum vitamins A, D, E, B(6), and B(12), carotenoids, folate, zinc, and selenium were measured at baseline. Frailty status was determined at baseline and during annual visits for 3 years of follow-up. RESULTS: At baseline, 250 women were frail and 516 women were not frail. Of 463 nonfrail women who had at least one follow-up visit, 205 (31.9%) became frail, with an overall incidence rate of 19.1 per 100 person-years. Compared with women in the upper three quartiles, women in the lowest quartile of serum carotenoids (hazard ratio [HR] 1.39; 95% confidence interval [CI], 1.01-1.92), alpha-tocopherol (HR 1.39; 95% CI, 1.02-1.92), and 25-hydroxyvitamin D (HR 1.34; 95% CI, 0.94-1.90) had an increased risk of becoming frail. The number of nutritional deficiencies (HR 1.10; 95% CI, 1.01-1.20) was associated with an increased risk of becoming frail, after adjusting for age, smoking status, and chronic pulmonary disease. Adjusting for potential confounders, we found that women in the lowest quartile of serum carotenoids had a higher risk of becoming frail (HR 1.54; 95% CI, 1.11-2.13). CONCLUSIONS: Low serum micronutrient concentrations are an independent risk factor for frailty among disabled older women, and the risk of frailty increases with the number of micronutrient deficiencies.
机译：背景：微量营养素缺乏症在老年人中很常见。我们假设低血清微量营养素浓度可预测社区中老年残疾妇女的身体虚弱。方法：我们从马里兰州巴尔的摩市的中度至重度残疾社区居民妇女人群研究中，对766名65岁及以上的女性进行了研究。在基线时测量血清维生素A，D，E，B（6）和B（12），类胡萝卜素，叶酸，锌和硒。在基线和在三年随访期间的年度访问期间确定脆弱状态。结果：基线时，250名女性虚弱，516名女性并不虚弱。在463位非脆弱女性中，至少有一次随访，其中205名（31.9％）变得虚弱，总发病率每100人年19.1。与处于最高四分之三位的女性相比，处于最低四分位的女性血清类胡萝卜素（危险比[HR] 1.39; 95％置信区间[CI]，1.01-1.92），α-生育酚（HR 1.39; 95％CI，1.02） -1.92）和25-羟基维生素D（HR 1.34; 95％CI，0.94-1.90）变得脆弱的风险增加。在调整了年龄，吸烟状况和慢性肺部疾病后，营养缺乏症的数量（HR 1.10; 95％CI，1.01-1.20）与身体虚弱的风险增加相关。调整潜在的混杂因素后，我们发现，血清类胡萝卜素含量最低的四分位数中的女性患上身体虚弱的风险更高（HR 1.54; 95％CI，1.11-2.13）。结论：低血清微量营养素浓度是残疾老年妇女虚弱的独立危险因素，并且随着微量营养素缺乏症的发生，虚弱的风险会增加。

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