Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats.

Alonso A; Fernandez R; Moreno M; Ordonez P; Gonzalez Pardo H; Conejo NM; Diaz F; Gonzalez C

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Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats.

机译：17β-雌二醇对卵巢切除的老年雌性大鼠胰岛素敏感性的积极影响。

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Aging is associated with insulin resistance, which represents a common factor in age-related diseases. We aimed to determine the role of 17beta-estradiol on insulin sensitivity and memory during aging using ovariectomized rats (2-26 months of age) treated with physiological doses of 17beta-estradiol. Our results indicate a lack of effect of 17beta-estradiol replacement on spatial memory assessed in a water maze. Conversely, estradiol treatment improved insulin sensitivity in aging rats. These data imply that relatively low doses of 17beta-estradiol may have beneficial effects on glucose homeostasis due to the protective effects of estrogen. However, estradiol treatment used in the present study did not prevent memory impairment associated with aging.

机译：衰老与胰岛素抵抗有关，胰岛素抵抗是与年龄有关的疾病的常见因素。我们旨在确定使用生理剂量的17β-雌二醇治疗的卵巢切除大鼠（2-26个月大）在衰老过程中17β-雌二醇对胰岛素敏感性和记忆的作用。我们的结果表明，在迷宫中评估17β-雌二醇替代品对空间记忆的影响不足。相反，雌二醇治疗可改善衰老大鼠的胰岛素敏感性。这些数据表明，由于雌激素的保护作用，相对低剂量的17β-雌二醇可能对葡萄糖稳态具有有益作用。但是，本研究中使用的雌二醇治疗不能预防与衰老相关的记忆障碍。

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来源
《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2006年第5期|共8页
作者
Alonso A; Fernandez R; Moreno M; Ordonez P; Gonzalez Pardo H; Conejo NM; Diaz F; Gonzalez C;
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正文语种 eng
中图分类内科学;
关键词
Aging; Estradiol; Estrogen Replacement Therapy; Insulin Resistance; 衰老; 雌二醇; 雌激素替代疗法; 胰岛素抗药性;

机译：Aging;Estradiol;Estrogen Replacement Therapy;Insulin Resistance;衰老;雌二醇;雌激素替代疗法;胰岛素抗药性;

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1. Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats. [J] . Alonso A, Fernandez R, Moreno M, The journals of gerontology.Series A. Biological sciences and medical sciences . 2006,第5期

机译：17β-雌二醇对卵巢切除的老年雌性大鼠胰岛素敏感性的积极影响。
2. Acute effects of 17 beta-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats. [J] . Alonso A, Gonzalez Pardo H, Garrido P, Age. . 2010,第4期

机译：17β-雌二醇和金雀异黄素对去卵巢卵巢雌性大鼠胰岛素敏感性和空间记忆的急性影响。
3. Positive Effects of 17β-Estradiol on Insulin Sensitivity in Aged Ovariectomized Female Rats [J] . Ana Alonso, Rebeca Fernández, María Moreno, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences . 2006,第5期

机译：17β-雌二醇对去卵巢老龄雌性大鼠胰岛素敏感性的正作用
4. Effect of Different Dose of 1 alpha OHD_3 on Bone Mass, Bone Strength and Histomorphometry in Ovariectomized Rats. [C] . Yan Xue, Fang Bao, Dong Li, International congress on osteoporosis . 1999

机译：不同剂量的1αOHD_3对卵巢大鼠骨质，骨强度和组织形态学的影响。
5. Effects of hyperinsulinemia, insulin sensitivity, and other factors associated with the insulin resistance syndrome on colorectal epithelial proliferation and carcinogenesis in rats. [D] . Tran, Thien Tram. 2003

机译：高胰岛素血症，胰岛素敏感性和其他与胰岛素抵抗综合征相关的因素对大鼠大肠上皮细胞增殖和致癌作用的影响。
6. Acute effects of 17β-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats [O] . Ana Alonso, Héctor González-Pardo, Pablo Garrido, 2010

机译：17β-雌二醇和金雀异黄素对去卵巢卵巢雌性大鼠胰岛素敏感性和空间记忆的急性影响
7. Positive Effects of 17ss-Estradiol on Insulin Sensitivity in Aged Ovariectomized Female Rats [O] . A. Alonso, R. Fernandez, M. Moreno, 2006

机译：17Ss-雌二醇对卵巢切除术大鼠胰岛素敏感性的积极作用

Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats.

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