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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age.
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The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age.

机译：衰老对雄性大鼠肝脏，内质网伴侣蛋白浓度的影响：由于伴侣蛋白的丧失而引起的蛋白质错折叠可能会随着年龄的增长而使生理功能下降。

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The endoplasmic reticulum (ER) chaperones are highly conserved proteins that catalyze the posttranslational processing of all secretory and membrane proteins. Our studies suggest that chaperone declines are one of the two central defects in Alzheimer's disease. We propose that similar declines in other organ systems underlie the physiological deficits of aging. Rats were maintained in a colony from age 21 days to death. Animals were killed at regular intervals, and hepatic, ER chaperone contents were determined by immunoblotting. ERp55, ERp57, ERp72, BiP, and calnexin constitutive levels declined 30%-50% with age. Calreticulin was unaffected. BiP (also known as GRP78), ERp55, and ERp57 showed marked swings with peaks occurring in midwinter and midsummer. This cyclics declined 73% with age. Considering the role of the ER chaperones in membrane and secretory protein posttranslational processing, these data support the concept that their loss could lead to many of the physiological declines associated with aging.
机译：内质网（ER）伴侣蛋白是高度保守的蛋白，可催化所有分泌蛋白和膜蛋白的翻译后加工。我们的研究表明，伴侣蛋白下降是阿尔茨海默氏病的两个主要缺陷之一。我们建议其他器官系统的类似下降是衰老的生理缺陷的基础。从21日龄到死亡，大鼠都被关在一个殖民地。定期杀死动物，并通过免疫印迹测定肝，ER伴侣含量。 ERp55，ERp57，ERp72，BiP和钙联接蛋白组成水平随年龄下降30％-50％。钙网蛋白未受影响。 BiP（也称为GRP78），ERp55和ERp57显示出明显的波动，并在仲冬和仲夏出现峰值。随着年龄的增长，这一周期下降了73％。考虑到ER伴侣在膜和分泌蛋白翻译后加工中的作用，这些数据支持这样的概念，即它们的丢失可能导致许多与衰老有关的生理衰退。

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