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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Efficacy and safety of statin monotherapy in older adults: a meta-analysis.
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Efficacy and safety of statin monotherapy in older adults: a meta-analysis.

机译：他汀类药物单一疗法在老年人中的疗效和安全性：一项荟萃分析。

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BACKGROUND: Statin therapy significantly reduces cardiovascular events. Older patients, however, are less likely to be prescribed statins than younger patients due to concern over lack of indication, lower predictive value of cholesterol levels, and increased risk of adverse events. To determine the effect of statins on all-cause mortality and on major cardiovascular events, including stroke, we performed a meta-analysis of statin trials that included older adult participants. METHODS: Mortality, cardiovascular events, and adverse event outcomes were extracted from published randomized, placebo-controlled clinical trials of persons aged 60 years and older. RESULTS: Data on 51,351 patients were evaluated. Statins reduced all-cause mortality by 15% (95% confidence interval, 7%-22%), coronary heart disease (CHD) death by 23% (15%-29%), fatal or nonfatal myocardial infarction (MI) by 26% (22%-30%), and fatal or nonfatal stroke by 24% (10%-35%). The relative risk of cancer comparing statins to placebo was 1.06 (0.95-1.18). Adverse event data were not consistently reported. CONCLUSIONS: Statin therapy significantly reduced all-cause and CHD mortality, as well as risk of stroke and MI. Statin therapy should be offered to older patients at high risk of atherosclerotic disease events.
机译：背景：他汀类药物疗法可显着减少心血管事件。然而，由于担心缺乏适应症，胆固醇水平的预测价值较低以及不良事件的风险增加，老年患者比年轻患者更难以开处方他汀类药物。为了确定他汀类药物对全因死亡率和主要心血管事件（包括中风）的影响，我们对包括老年人在内的他汀类药物试验进行了荟萃分析。方法：从已发表的随机，安慰剂对照的60岁及以上老年人的临床试验中提取死亡率，心血管事件和不良事件的结局。结果：对51,351例患者的数据进行了评估。他汀类药物可使全因死亡率降低15％（95％置信区间，7％-22％），使冠心病（CHD）死亡降低23％（15％-29％），使致命或非致命性心肌梗塞（MI）降低26 ％（22％-30％），致命或非致命性中风增加24％（10％-35％）。他汀类药物与安慰剂相比，癌症的相对风险为1.06（0.95-1.18）。不良事件数据未得到一致报告。结论：他汀类药物治疗可显着降低全因和冠心病死亡率，以及中风和心肌梗死的风险。应向有动脉粥样硬化疾病事件高风险的老年患者提供他汀类药物治疗。

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