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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Inflammation and rate of cognitive change in high-functioning older adults.
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Inflammation and rate of cognitive change in high-functioning older adults.

机译：高功能老年人的炎症反应和认知变化率。

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BACKGROUND: Inflammatory proteins including interleukin-6 (IL-6) and C-reactive protein (CRP) have been associated with incident cognitive impairment, but little research has addressed their effects on the rate of cognitive change, and findings are mixed. The purpose of this study was to examine the relationship between serum levels of IL-6 and CRP and the rate of cognitive change across a range of cognitive domains in a sample of healthy older persons. METHODS: Growth curve analysis was performed on data from the MacArthur Study of Successful Aging, a longitudinal cohort study of high-functioning older adults aged 70-79 years at baseline in 1988 and reinterviewed in 1991 and 1995 (N = 851). Individual growth curve parameters were derived from baseline and follow-up performance in abstraction, language, spatial ability, verbal recall, spatial recognition, and global cognitive function based on age, IL-6, CRP, and covariates. RESULTS: Cross-sectionally, there is a generally linear negative relationship between inflammation and cognition, such that higher levels of inflammation are associated with lower levels of baseline cognitive function. After controlling for potential confounders, there was no effect of inflammation on baseline cognitive function or the rate of longitudinal cognitive change. However, persons in the top tertile on IL-6 were at an increased risk of incident declines on the Short Portable Mental Status Questionnaire (SPMSQ). CONCLUSIONS: Although high levels of inflammation are associated with incident cognitive impairment, these results do not generalize to the full range of cognitive changes, where the role of inflammation appears to be marginal.
机译：背景：包括白细胞介素6（IL-6）和C反应蛋白（CRP）在内的炎症蛋白已与事件性认知障碍相关，但很少有研究探讨它们对认知变化率的影响，研究结果好坏参半。这项研究的目的是检查健康老年人样本中IL-6和CRP的血清水平与认知范围内认知变化率之间的关系。方法：根据MacArthur成功衰老研究的数据进行生长曲线分析。MacArthur成功衰老研究是一项针对1988年基线时年龄在70-79岁的高功能老年人的纵向队列研究，并于1991年和1995年进行了重新访谈（N = 851）。个体生长曲线参数是根据年龄，IL-6，CRP和协变量从基线和后续表现的抽象，语言，空间能力，言语回忆，空间识别和整体认知功能中得出的。结果：从横截面来看，炎症和认知之间通常存在线性负相关关系，因此炎症水平越高，基线认知功能水平越低。在控制了潜在的混杂因素之后，炎症对基线认知功能或纵向认知变化率没有影响。然而，在IL-6上处于最高三分位数的人在短期便携式心理状态调查表（SPMSQ）上发生事件下降的风险增加。结论：尽管炎症的高发与认知功能障碍有关，但这些结果并未推广到整个认知变化范围，而炎症的作用似乎很小。

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