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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women.
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Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women.

机译：Alpha-actinin-3（ACTN3）R577X多态性影响年龄较大的男性和女性对力量训练的膝盖伸肌峰值功率反应。

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BACKGROUND: The alpha-actinin-3 (ACTN3) R577X polymorphism has been associated with muscle power performance in cross-sectional studies. METHODS: We examined baseline knee extensor concentric peak power (PP) and PP change with approximately 10 weeks of unilateral knee extensor strength training (ST) using air-powered resistance machines in 71 older men (65 [standard deviation = 8] years) and 86 older women (64 [standard deviation = 9] years). RESULTS: At baseline in women, the XX genotype group had an absolute (same resistance) PP that was higher than the RR (p =.005) and RX genotype groups (p =.02). The women XX group also had a relative (70% of one-repetition maximum [1-RM]) PP that was higher than that in the RR (p =.002) and RX groups (p =.008). No differences in baseline absolute or relative PP were observed between ACTN3 genotype groups in men. In men, absolute PP change with ST in the RR (n = 16) group approached a significantly higher value than in the XX group (n = 9; p =.07). In women, relative PP change with ST in the RR group (n = 16) was higher than in the XX group (n = 17; p =.02). CONCLUSIONS: The results indicate that the ACTN3 R577X polymorphism influences the response of quadriceps muscle power to ST in older adults.
机译：背景：在横断面研究中，α-actinin-3（ACTN3）R577X多态性与肌肉力量表现有关。方法：我们使用气动阻力机在71名年龄较大的男性（65岁[标准差= 8]岁）中使用气动阻力机检查了大约10周的单侧膝伸肌力量训练（ST）的基线膝伸肌同心峰值功率（PP）和PP变化。 86名老年妇女（64 [标准差= 9]岁）。结果：在女性基线时，XX基因型组的绝对（相同抵抗力）PP高于RR（p = .005）和RX基因型组（p = .02）。女性XX组的相对PP（一次重复最高[1-RM]的70％）也高于RR组（p = .002）和RX组（p = .008）。在男性ACTN3基因型组之间未观察到基线绝对PP或相对PP的差异。在男性中，RR（n = 16）组中ST的绝对PP变化值明显高于XX组（n = 9; p = .07）。在女性中，RR组（n = 16）的ST相对PP变化高于XX组（n = 17; p = .02）。结论：结果表明ACTN3 R577X基因多态性影响老年人股四头肌对ST的反应。

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