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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of an exercise intervention on immunologic parameters in frail elderly nursing home residents.
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Effects of an exercise intervention on immunologic parameters in frail elderly nursing home residents.

机译：运动干预对年迈体弱的养老院居民免疫学参数的影响。

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BACKGROUND: Aging is associated with decline in both cell-mediated and humoral immunity and may contribute to increased incidence and severity of infections in frail elderly. Exercise, depending on intensity, has significant effects on the immune system. We conducted a randomized, controlled clinical trial of a 32-week functionally oriented exercise program in frail elderly living in nursing homes and determined whether the exercise intervention was associated with a change in immune parameters in this frail elderly nursing home population. METHODS: Nursing home residents were randomly assigned to an intervention (n = 94) and control group (n = 96). The intervention consisted of a functionally oriented endurance and resistance exercise training that was provided every 2 hours from 8:00 AM to 4:00 PM for 5 days a week for 8 months. Lymphocyte subpopulations, including activation markers (CD28, CD25, HLA-DR), in vitro proliferation, and soluble products of cytokine activity (neopterin and sTNF-RII) in serum were measured by taking blood samples at baseline and after 8 weeks and 32 weeks of the intervention. RESULTS: Exercise training did not induce changes in lymphocyte subpopulations, activation markers (CD28, CD25, HLA-DR), in vitro proliferation, and soluble products of cytokine activity (neopterin and sTNF-RII) in serum. CONCLUSIONS: A 32-week exercise intervention did not bring about beneficial or detrimental effects on immune parameters in the frail elderly nursing home population and may explain why the intervention was not associated with a change in the incidence of infections in the intervention group compared with the control group.
机译：背景：衰老与细胞介导的和体液免疫力的下降有关，并且可能导致体弱的老年人感染的发生率和严重性增加。运动取决于强度，对免疫系统有重要影响。我们对居住在疗养院中的体弱老年人进行了为期32周的以功能为导向的锻炼计划的随机对照临床试验，并确定了运动干预是否与该体弱的老年人疗养院人群的免疫参数变化相关。方法：将疗养院居民随机分为干预组（n = 94）和对照组（n = 96）。干预包括以功能为导向的耐力和阻力运动训练，该训练从上午8:00到下午4:00每2小时提供一次，为期8个月，每周5天。通过在基线时以及在8周和32周后采集血样来测量血清中的淋巴细胞亚群，包括激活标志物（CD28，CD25，HLA-DR），体外增殖和血清中细胞因子活性的可溶性产物（新蝶呤和sTNF-RII）。的干预。结果：运动训练并未引起血清中淋巴细胞亚群，激活标记（CD28，CD25，HLA-DR），体外增殖和细胞因子活性可溶性产物（新蝶呤和sTNF-RII）的变化。结论：为期32周的运动干预对脆弱的老年人疗养院人群的免疫指标没有带来有益或有害的影响，并且可以解释为什么与干预组相比，干预与干预组感染率的变化不相关。控制组。

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