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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascu
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Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascu

机译：老年人血脂异常与动脉粥样硬化性血管疾病和痴呆症，无痴呆的动脉粥样硬化性血管疾病，无动脉粥样硬化性血管疾病的痴呆症，无痴呆症或动脉粥样硬化性血管疾病的关联

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BACKGROUND: Observational data have shown that the use of statins was associated with a lower prevalence of vascular dementia and of Alzheimer's disease. METHODS: We investigated in an academic nursing home the association of dyslipidemia with atherosclerotic vascular disease (group 1), atherosclerotic vascular disease without dementia (group 2), dementia without atherosclerotic vascular disease (group 3), and no dementia or atherosclerotic vascular disease (group 4). RESULTS: Increased serum low-density lipoprotein (LDL) cholesterol was present in 36 of 50 group 1 patients (72%), in 34 of 50 group 2 patients (68%), in 34 of 50 group 3 patients (68%), and in 18 of 50 group 4 patients (36%) (p =.0003 for 1 versus 4; p = 0.001 for 2 versus 4 and 3 versus 4). Decreased serum high-density lipoprotein (HDL) cholesterol was present in 34 of 50 group 1 patients (68%), in 35 of 50 group 2 patients (70%), in 32 of 50 group 3 patients (64%), and in 16 of 50 group 4 patients (32%) (p =.0003 for 1 versus 4; p =.0001 for 2 versus 4; p =.001 for 3 versus 4). Hypertriglyceridemia was not significantly different in the 4 groups. CONCLUSIONS: The prevalence of increased serum LDL cholesterol and decreased serum HDL cholesterol were significantly higher in elderly patients with atherosclerotic vascular disease plus dementia, atherosclerotic vascular disease without dementia, and dementia without atherosclerotic vascular disease than in patients with no dementia or atherosclerotic vascular disease.
机译：背景：观察数据表明，他汀类药物的使用与血管性痴呆和阿尔茨海默氏病的患病率较低相关。方法：我们在一家学术养老院中调查了血脂异常与动脉粥样硬化性血管疾病（第1组），无痴呆的动脉粥样硬化性血管疾病（第2组），无动脉粥样硬化性血管疾病的痴呆（第3组）以及无痴呆症或动脉粥样硬化性血管疾病（组4）。结果：50例1组患者中的36例（72％），50例2组患者中的34例（68％），50例3组患者中的34例（68％）的血清低密度脂蛋白（LDL）胆固醇升高，在50个小组中的18个小组中，有4个患者（36％）（p = 0.0003，1对4; p = 0.001，2对4和3对4）。 50例1组患者中的34例（68％），50例2组患者中的35例（70％），50例3组患者中的32例（64％）和9例患者中血清高密度脂蛋白（HDL）胆固醇降低50个第4组患者中的16个（32％）（1对4对p = .0003; 2对4对p = .0001; 3对4对p = .001）。高甘油三酯血症在4组中无显着差异。结论：与没有痴呆或动脉粥样硬化性血管疾病的老年患者相比，患有动脉粥样硬化性血管疾病加痴呆，无痴呆的动脉粥样硬化性血管疾病和无动脉粥样硬化性血管疾病的老年性痴呆的患者血清LDL胆固醇升高和血清HDL胆固醇降低的发生率明显更高。

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