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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial.
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Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial.

机译：睾丸激素替代和/或抵抗训练对摄入醋酸孕甾酮的老年男性白细胞介素-6，肿瘤坏死因子α和瘦素的影响：一项随机对照试验。

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BACKGROUND: Megestrol acetate (MA) has been used to stimulate weight gain in elderly populations with the majority of the gain being adipose tissue. Significant inverse correlations have been reported between weight gain with MA and reductions in circulating the tumor necrosis factor (TNF) alpha receptors. In addition, MA has been shown to reduce circulating interleukin 6 (IL-6) concentrations. We attempted to increase gains in fat-free mass with MA using resistance training and/or testosterone replacement and examined the effects on circulating IL-6, TNF alpha, and leptin in elderly men. METHODS: All subjects received MA and were randomly assigned to one of these four groups: placebo (P) injections; resistance training and P (RT+P); weekly injections of testosterone (T; 100 mg/wk); or RT and T (RT+T). Cytokines were measured by enzyme-linked immunosorbent assay Preinterventions, Midinterventions, and after 12 weeks of the interventions (Post). RESULTS: IL-6 decreased ( p =.03) over time for the T and P groups when compared to the RT+T and RT+P groups. A time effect ( p =.013) was observed for TNF alpha with Mid and Post both being lower than Pre. A hormone by time interaction ( p =.03) was observed for plasma leptin with individuals not on T exhibiting higher concentrations Post than those individuals on T. A positive correlation was observed (r =.60; p <.05) between changes in fat mass and the change in leptin. CONCLUSION: IL-6 was reduced by MA except when RT was undertaken; TNF alpha was reduced over time regardless of group; leptin was higher in individuals not on T than those on T; and the change in plasma leptin was correlated with the change in fat mass.
机译：背景：醋酸孕甾酮（MA）已被用于刺激老年人口体重增加，其中大部分增加是脂肪组织。据报道，MA体重增加与循环肿瘤坏死因子（TNF）α受体减少之间存在显着的负相关关系。此外，MA已显示可降低循环白介素6（IL-6）的浓度。我们试图通过抵抗训练和/或睾丸激素替代来增加MA的无脂体重，并研究了其对老年男性循环IL-6，TNFα和瘦素的影响。方法：所有受试者均接受MA治疗，并随机分为以下四组之一：安慰剂（P）注射;阻力训练和P（RT + P）;每周注射一次睾丸激素（T; 100 mg / wk）;或RT和T（RT + T）。通过干预前，中期干预以及干预12周后（Post），通过酶联免疫吸附测定法测量细胞因子。结果：与RT + T和RT + P组相比，T和P组的IL-6随时间下降（p = .03）。对于TNFα，观察到时间效应（p ＝ .013），其中Mid和Post均低于Pre。对于血浆瘦素，观察到激素与时间的相互作用（p = .03），未处于T的个体的Post浓度高于那些处于T的个体。观察到的瘦素之间的变化呈正相关（r = .60; p <.05）。脂肪量和瘦素的变化。结论：MA可以降低IL-6的水平，但RT除外。 TNFα随时间降低而与组无关未服用T的个体的瘦素水平高于服用T的个体。血浆瘦素的变化与脂肪量的变化相关。

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