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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices.
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Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices.

机译：身体虚弱和心脏自主神经控制功能受损：传统心率变异性指数的主成分汇总产生新见解。

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BACKGROUND: Age-related deterioration in homeostatic regulatory mechanisms leads to decreased complexity in their output. For example, the degradation of cardiac autonomic control results in loss of complexity in the heart rate signal. Frailty is a state of critically impaired homeostasis that results in heightened vulnerability to stressors. We propose a new measure of heart rate variability (HRV) to capture the impairment in cardiac autonomic control associated with frailty. METHODS: Traditional time and frequency domain indices of HRV were obtained from 2-hour ambulatory electrocardiograms (ECGs) of 276 women (65-101 years old) in the Women's Health and Aging Study-I. Principal components analysis was conducted on the correlation matrix of HRV indices. Frailty was defined using a validated instrument. Regression models were used to evaluate associations of HRV measures with age, frailty, and 5-year mortality. RESULTS: The first two principal components (PCs), PC1 and PC2, explained 90% of the variance in HRV indices. PC1 is the mean of log-transformed HRV indices. PC2 is a linear combination of log-transformed indices, with positive weights for very low frequency (VLF), low frequency (LF), and standard deviation of N-N intervals (SDNN), and negative weights for high frequency (HF), root-mean-squared differences of successive N-N intervals (RMSSD), and proportion of all N-N intervals that are larger than 50 ms (pNN50). Decreases in SDNN, VLF, LF, and LF/HF were associated with an increased risk of frailty. PC2 was more strongly associated with age (beta = -.23, p < .001) and frailty (beta = -.73, p < 10(-5)) than were the individual HRV indices and LF/HF. PC2 was also the best predictor of 5-year mortality (beta = -.60, p < 10(-6)). CONCLUSIONS: Cardiac autonomic control, as reflected by HRV, is impaired in frailty. A new measure derived from PC aggregation of traditional HRV indices provides a compact summary of this impairment.
机译：背景：与年龄有关的稳态调节机制的恶化导致其输出复杂性降低。例如，心脏自主控制的退化导致心律信号复杂性的丧失。脆弱是体内稳态严重受损的一种状态，导致对压力源的脆弱性增加。我们提出一种新的心率变异性（HRV）量度，以捕获与体弱相关的心脏自主神经控制障碍。方法：根据《妇女健康与老年研究I》中276名女性（65-101岁）的2小时动态心电图（ECG）获得传统的HRV时域和频域指数。对HRV指数的相关矩阵进行主成分分析。脆弱是使用经过验证的工具定义的。回归模型用于评估HRV量度与年龄，虚弱和5年死亡率的关联。结果：前两个主要成分（PC）PC1和PC2解释了90％的HRV指数方差。 PC1是对数转换后的HRV指数的平均值。 PC2是对数转换索引的线性组合，其中极低频（VLF），低频（LF）和NN间隔的标准偏差（SDNN）带有正权重，高频（HF）带有负权重，根均根连续NN间隔（RMSSD）的均方差以及大于50 ms的所有NN间隔的比例（pNN50）。 SDNN，VLF，LF和LF / HF的减少与体弱的风险增加相关。与单独的HRV指数和LF / HF相比，PC2与年龄（β= -.23，p <.001）和虚弱（β= -.73，p <10（-5））的关联更强。 PC2还是5年死亡率的最佳预测指标（β= -.60，p <10（-6））。结论：HRV反映出心脏的自主神经控制功能虚弱。从传统HRV指数的PC聚合中得出的一项新指标提供了该减损的简明摘要。

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