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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity.
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Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity.

机译：卡路里限制对与年龄有关的认知下降的措施的影响：增加体育锻炼的作用。

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Controversy exists as to whether lifelong 40% calorie restriction (CR) enhances, has no effect on, or disrupts cognitive function during aging. Here, we report the effects of CR versus ad-lib feeding on cognitive function in male Brown Norway x Fisher344 rats across a range of ages (8-38 months), using two tasks that are differentially sensitive to age-related cognitive decline: object recognition and Morris water maze (MWM). All ages performed equally in object recognition, whereas, as a group, CR rats were impaired. In contrast, there was an age-related impairment in the MWM that was attenuated by CR as measured by time in proximity with and latency to reach the platform. Distance to the platform, a more sensitive measure, was not affected by CR. Finally, CR resulted in an overall increase in physical activity, one of several behavioral confounders to consider in the interpretation of cognitive outcomes in both tasks.
机译：关于终身40％卡路里限制（CR）是否在衰老过程中增强，不影响或破坏认知功能存在争议。在这里，我们报告了CR和ad-lib进食对年龄不同（8-38个月）的雄性Brown Norway x Fisher344大鼠的认知功能的影响，使用了对年龄相关的认知下降有不同敏感性的两项任务：识别和莫里斯水迷宫（MWM）。所有年龄段的对象识别性能均相同，而作为一组的CR大鼠则受损。相比之下，MWM中存在与年龄相关的损伤，该损伤可以通过CR衰减，如通过接近平台和到达平台的时间来衡量。到平台的距离（一种更敏感的度量）不受CR影响。最后，CR导致体育活动总体增加，这是在两个任务的认知结果解释中要考虑的几个行为混杂因素之一。

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