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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Aging-related alterations of subtelomeric methylation in sarcoidosis patients
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Aging-related alterations of subtelomeric methylation in sarcoidosis patients

机译：结节病患者端粒亚甲基化的衰老相关改变

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摘要

Telomeres in somatic cells become shorter with aging, and the shortening is accelerated by pathophysiological conditions. Telomere shortening can be influenced by subtelomeric DNA methylation. The telomere length and subtelomeric methylation status in peripheral leukocytes were compared in healthy controls and sarcoidosis patients. The sarcoidosis patients revealed shorter telomeres and a faster attrition of telomere shortening in comparison with healthy controls. Both healthy controls and sarcoidosis patients showed that long telomeres (>9.4 kb) decrease and short telomeres (<4.4 kb) increase with aging, accompanying relative increases of long telomeres with subtelomeric hypermethylation and short telomeres with subtelomeric hypomethylation. This suggested that the aging-related telomere shortening is associated with the surrounding subtelomeric hypomethylation. Furthermore, sarcoidosis patients showed this alteration of the subtelomeric methylation earlier than controls (in their 60s or later). This altered subtelomeric hypomethylation may correspond to the accelerated telomere shortening in sarcoidosis. This also means that the subtelomeric hypomethylation can be also influenced by certain disease conditions.
机译：体细胞中的端粒随着年龄的增长而变短，而这种缩短因病理生理条件而加速。端粒缩短可能受到亚端粒DNA甲基化的影响。在健康对照和结节病患者中比较了外周血白细胞的端粒长度和亚端粒甲基化状态。与健康对照组相比，结节病患者的端粒较短，端粒的磨损更快。健康对照组和结节病患者均显示，随着年龄的增长，长端粒减少（> 9.4 kb），短端粒增加（<4.4 kb），伴随着亚端粒高甲基化的长端粒和亚端粒亚甲基化的短端粒的相对增加。这表明与衰老有关的端粒缩短与周围的亚端粒亚甲基化不足有关。此外，结节病患者显示亚端粒甲基化的这种改变比对照更早（在60岁或更晚）。这种改变的亚端粒亚甲基化不足可能与结节病中端粒加速缩短有关。这也意味着亚端粒的低甲基化也可能受到某些疾病状况的影响。

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