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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women.
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White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women.

机译：在社区居住的老年妇女中，白细胞计数，胰岛素样生长因子-1水平和虚弱。

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BACKGROUND: Elevated white blood cell (WBC) counts and decreased insulin-like growth factor-1 (IGF-1) levels are individually associated with frailty in older adults. WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated. METHODS: Baseline data from 696 community-dwelling older women in the Women's Health and Aging Study I were included in this cross-sectional analysis. Multivariate linear regression analysis was performed to assess the relationship between WBC counts and IGF-1 levels. Odds ratios (ORs) for frailty were evaluated across tertiles of WBC counts and IGF-1 levels, adjusting for age, race, education, body mass index, and smoking. RESULTS: WBC counts correlated with IGF-1 levels (Spearman coefficient: .10, p < .01). Compared with participants in the low WBC and high IGF-1 tertiles (reference group), those in the low WBC and low IGF-1 tertiles had OR of 2.33 for frailty (95% confidence interval [CI]: 1.04-3.65, p < .05), those in the high WBC and high IGF-1 tertiles had OR of 3.86 (95% CI: 1.13-4.07, p < .01), and those in the high WBC and low IGF-1 tertiles had OR of 3.61 (95% CI: 1.64-4.97, p < .01), adjusting for covariates. CONCLUSIONS: These findings demonstrate in vivo correlation between WBC and IGF-1. They suggest U-shaped joint associations of WBC and IGF-1 with frailty, with the strongest association at adverse levels of both. They also provide a basis for further investigation into the complex immune-endocrine dysregulations in frailty.
机译：背景：白细胞（WBC）计数升高和胰岛素样生长因子-1（IGF-1）水平降低分别与老年人的体弱相关。已知WBC亚群可在体外产生IGF-1并表达IGF-1受体。但是，尚未研究WBC和IGF-1之间的体内关系及其对衰弱的共同贡献。方法：本横断面分析中包括了《妇女健康与老年研究I》中来自696名居住在社区中的老年妇女的基线数据。进行多元线性回归分析以评估WBC计数与IGF-1水平之间的关系。在WBC计数和IGF-1水平的三分位数之间评估了脆弱性的赔率（OR），并调整了年龄，种族，教育程度，体重指数和吸烟率。结果：白细胞计数与IGF-1水平相关（Spearman系数：.10，p <.01）。与低WBC和高IGF-1三分位数的参与者（参考组）相比，低WBC和低IGF-1三分位数的参与者的脆弱性OR为2.33（95％置信区间[CI]：1.04-3.65，p < .05），高WBC和高IGF-1三分位数者的OR为3.86（95％CI：1.13-4.07，p <.01），高WBC和低IGF-1三分位数者的OR为3.61 （95％CI：1.64-4.97，p <.01），调整了协变量。结论：这些发现证明了WBC和IGF-1之间的体内相关性。他们认为，WBC和IGF-1的U形关节联合体虚弱，在两者的不利水平上最强的联合体。它们还为进一步研究脆弱的复杂免疫-内分泌失调提供了基础。

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