...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Comparative biology of aging.
【24h】

Comparative biology of aging.

机译：衰老的比较生物学。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Virtually, all research on basic mechanisms of aging has used species that are short lived and thus demonstrably unsuccessful at combating basic aging processes. A novel comparative approach would use a diversity of populations and species, focusing on those with particularly long, healthy lives, seeking the causative mechanisms that distinguish them from shorter lived relatives. Species of interest from this perspective include the naked mole rat, a mouse-size rodent that lives up to 30 years in the laboratory, and the little brown bat, which lives up to 34 years in the wild. Comparisons among dogs of different sizes, which differ by more than 50% in health span might also prove rewarding, as might novel species chosen because of their similarity to humans in certain key traits. Primates, because of their sophisticated cognitive ability, are a group of special value, and small, short-lived primates like the common marmoset might prove especially beneficial. Cell repositories and tissue banks from key species, as well as genomic and analytic tools optimized for comparative studies, would make valuable contributions to a new comparative approach to basic aging research.
机译：实际上，所有有关衰老基本机制的研究都使用了寿命短的物种，因此在对抗基本衰老过程中显然没有成功。一种新颖的比较方法将利用人口和物种的多样性，着重于那些寿命特别长，健康的人，寻求将其与寿命较短的亲戚区分开来的致病机制。从这个角度来看，感兴趣的物种包括裸鼠，老鼠大小的啮齿动物，其在实验室中的寿命可达30年;以及棕褐色的蝙蝠，其在野外的寿命可达34年。在不同大小的狗之间进行比较，它们之间的健康期差异超过50％，也可能会有所裨益，因为某些新品种由于在某些关键特征上与人的相似性而被选中，这可能也会有所收获。灵长类动物由于其复杂的认知能力而具有特殊的价值，而寿命短的灵长类灵长类动物（如普通prove猴）可能特别有益。来自关键物种的细胞储存库和组织库，以及为比较研究而优化的基因组和分析工具，将为基础衰老研究的一种新的比较方法做出宝贵的贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号