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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Toward a systems biology framework for understanding aging and health span.
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Toward a systems biology framework for understanding aging and health span.

机译：建立了解衰老和健康期的系统生物学框架。

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摘要

It is argued that aging research is at a stage where it could benefit greatly from a more intense engagement with the perspectives emphasized by systems biology and complexity science. A more integrated, systematic approach is needed if we are ever to have a fully developed, fundamental understanding of aging, longevity, and their relationship to health. A broader, deeper, more quantitative, and predictive conceptual framework can lead to theoretical approaches and realistic models that can be quantitatively confronted with data and, perhaps more importantly, stimulate novel questions and novel experiments. Integral to this is the search for underlying causal multilevel mechanisms and principles that can be quantified and developed into a serious predictive theoretical framework, providing a point of departure for framing a more integrated research agenda.
机译：有人认为，老化研究正处于一个阶段，在该阶段中，如果更深入地参与系统生物学和复杂性科学所强调的观点，则可以大大受益。如果我们要对衰老，寿命及其与健康的关系有一个全面的，基本的了解，就需要一种更加综合，系统的方法。一个更广泛，更深入，更定量和更具预测性的概念框架可以导致可以定量地与数据面对的理论方法和现实模型，并且也许更重要的是可以激发新问题和新实验。对此不可或缺的是寻找可以量化并发展为严肃的预测性理论框架的潜在因果多级机制和原则，这为制定更为综合的研究议程提供了切入点。

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