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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >'Dividends' from research on aging--can biogerontologists, at long last, find something useful to do?
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'Dividends' from research on aging--can biogerontologists, at long last, find something useful to do?

机译：来自衰老研究的“红利”-生物老年学家能否最终找到有用的东西？

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摘要

Biogerontologists and demographers have argued that the fastest, most cost-effective strategies for prevention of the medical problems that afflict those older than 60 years are likely to emerge from a deeper understanding of what factors time the aging process and how aging leads, in rough synchrony, to the many diseases and disabilities of aging. Biologists can support and refine this discussion by studies of slow-aging mice, of mice with disease-promoting mutations, of mice in which specific cellular responses have been abrogated by genetic or pharmaceutical interventions, of slow-aging dog and horse breeds, and of the factors, genetic and physiological, that coordinate lethal and nonlethal consequences of aging in people. More work is also needed to learn how timing of antiaging interventions can be used to optimize the balance between beneficial and undesirable effects.
机译：生物老年病学家和人口统计学家认为，最快，最具成本效益的战略来预防困扰60岁以上老年人的医学问题，可能是由于对衰老过程的影响因素以及衰老如何导致的更深刻理解而产生的，给许多疾病和衰老带来障碍。生物学家可以通过研究慢龄小鼠，具有疾病促进突变的小鼠，通过遗传或药物干预消除了特定细胞应答的小鼠，慢龄狗和马品种以及遗传和生理因素，可以协调人的衰老的致命和非致命后果。还需要做更多的工作来学习如何使用抗衰老干预措施的时机来优化有益和不良影响之间的平衡。

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