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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Age-related changes in subtelomeric methylation in the normal Japanese population.
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Age-related changes in subtelomeric methylation in the normal Japanese population.

机译：正常日本人群中与年龄相关的亚端粒甲基化变化。

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BACKGROUND: The telomeres of somatic cells become shorter with individual aging. However, no significant change in subtelomeric methylation of somatic cells with aging has yet been reported. METHODS: Telomere lengths of the peripheral blood cells of 148 normal Japanese were analyzed by Southern blotting using methylation-sensitive and -insensitive isoschizomers. RESULTS: With aging, long telomeres decrease and short telomeres increase, and the contents of the telomeres with methylated subtelomere increase in long telomeres, thus leading us to postulate that telomeres with less methylated subtelomeres tend to become shortened faster. CONCLUSIONS: A telomere length distribution analysis with methylation-sensitive and -insensitive isoschizomer seems to be a useful tool to assess the subtelomeric methylation status of the somatic cell population. The subtelomeric methylation of peripheral blood cells is also indicated to be an indicator for aging-associated genomic changes.
机译：背景：随着个体衰老，体细胞的端粒变短。然而，尚未发现随着年龄的增长体细胞亚端粒甲基化的显着变化。方法：采用甲基化敏感和不敏感同工酶，通过Southern印迹分析148例正常日本人外周血细胞的端粒长度。结果：随着年龄的增长，长端粒的端粒减少而长端粒的增加，端粒含量的增加使甲基化亚端粒的含量增加，因此我们推测甲基化亚端粒较少的端粒倾向于更快地缩短。结论：端粒长度分布分析与甲基化敏感和不敏感的异构体似乎是评估体细胞亚端粒甲基化状态的有用工具。外周血细胞的亚端粒甲基化也被指示为与衰老相关的基因组变化的指标。

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