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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Weight loss and low-intensity exercise for the treatment of metabolic syndrome in obese postmenopausal women.
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Weight loss and low-intensity exercise for the treatment of metabolic syndrome in obese postmenopausal women.

机译：减肥和低强度运动可治疗绝经后肥胖女性的代谢综合征。

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BACKGROUND: The prevalence of the metabolic syndrome (MetSyn) approaches 50% in postmenopausal women. This study examines the efficacy of lifestyle modification for the treatment of MetSyn and its associated risk for cardiovascular disease and diabetes in this population. METHODS: This prospective controlled study examines the effects of a 6-month weight loss and low-intensity exercise program (WL+LEX) on body composition (dual-energy X-ray absorptiometry and abdominal computed tomography scans), fasting glucose and lipid levels, cytokines, and blood pressure in postmenopausal women with and without MetSyn. RESULTS: WL+LEX reduced body weight (MetSyn: -5% vs non-MetSyn: -7%) and fat mass (-11% vs -15%) and increased VO(2max) (+2% vs +3%) in both MetSyn (N = 35) and non-MetSyn (N = 41) groups. Constituents of MetSyn decreased comparably in both groups. Fifteen (45%) MetSyn participants responded (R) by converting to non-MetSyn, 18 remained MetSyn (NR), and 2 had missing data. Reduction in fat mass (-15% vs -8%, p = .02) was greater in R than NR, but there were no between-group differences in changes in VO(2max), cytokines, or other variables. The decrease in the number of MetSyn criteria was greater in R than in NR (-27 vs -13, p < .0001) due to decreases in blood pressure (p < .01), glucose (p = .02), and with a trend for triglyceride (p = .07). Reductions in fat mass best predicted resolution of MetSyn (p = .04). CONCLUSIONS: Women who lose more fat are more likely to lower blood pressure, glucose, and triglyceride levels to resolve MetSyn. Thus, a WL+LEX program effectively treats postmenopausal women with MetSyn.
机译：背景：绝经后妇女的代谢综合征（MetSyn）患病率接近50％。这项研究检查了生活方式改变对MetSyn的治疗功效及其在该人群中发生心血管疾病和糖尿病的相关风险。方法：这项前瞻性对照研究检查了为期6个月的减肥和低强度运动计划（WL + LEX）对身体成分（双能X线吸收和腹部CT扫描），空腹血糖和血脂水平的影响有或没有MetSyn的绝经后妇女的血脂，细胞因子和血压。结果：WL + LEX降低了体重（MetSyn：-5％，而非MetSyn：-7％）和脂肪量（-11％：-15％），VO（2max）增加（+2％，+ 3％）在MetSyn（N = 35）和非MetSyn（N = 41）组中。两组中MetSyn的成分相对减少。 15名（45％）MetSyn参与者通过转换为非MetSyn做出了回应（R），剩下18名MetSyn（NR），还有2名缺少数据。 R的脂肪量减少（-15％vs -8％，p = .02）比NR大，但VO（2max），细胞因子或其他变量的变化没有组间差异。由于血压（p <.01），葡萄糖（p = .02）和血压的降低，R中MetSyn标准数目的减少比NR中的减少更大（-27对-13，p <.0001）。甘油三酸酯的趋势（p = .07）。减少脂肪量可以最好地预测MetSyn的分辨率（p = .04）。结论：失去更多脂肪的女性更有可能降低血压，葡萄糖和甘油三酸酯水平来解决MetSyn。因此，WL + LEX程序可有效治疗MetSyn绝经后妇女。

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