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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Urine Concentrating and Diluting Ability During Aging
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Urine Concentrating and Diluting Ability During Aging

机译：老化过程中尿液的浓缩和稀释能力

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摘要

Urine concentrating ability is reduced during normal aging in people and rats. The abundance of many of the key transport proteins that contribute to urine concentrating ability is reduced in the kidney medulla of aged rats. The reductions in water, sodium, and urea transport protein abundances, and their reduced response to water restriction, contribute to the reduced ability of aged rats to concentrate their urine and conserve water. If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced urine concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability and/or nocturnal polyuria.
机译：人和大鼠正常衰老过程中尿液浓缩能力降低。在老年大鼠的肾脏髓质中，许多有助于尿液浓缩能力的关键转运蛋白的含量降低了。水，钠和尿素转运蛋白丰度的降低，以及它们对水分限制的响应降低，导致衰老大鼠浓缩尿液和节约水的能力降低。如果在人类肾脏中发生类似的机制，它将为衰老中尿液浓缩能力降低提供分子解释，并可能为改善尿液浓缩能力和/或夜间多尿症的新型治疗方法提供机会。

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