...
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.
【24h】

Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.

机译:APOEε2等位基因对最老的老年人的死亡率和认知功能的影响。

获取原文
获取原文并翻译 | 示例
           

摘要

Some studies indicate that the APOE ε2 allele may have a protective effect on mortality and mental health among the elderly adults. We investigated the effect of the APOE ε2 allele on cognitive function and mortality in 1651 members of the virtually extinct Danish 1905 birth cohort. We found no protective effect of the APOE ε2 allele on mortality compared with the APOE ε3 allele. The point estimates indicated an increased protection against cognitive decline over time for persons with the APOE ε2 allele. Cognitive score did not significantly modify the mortality risk of the various APOE genotypes. We did not find a protective effect of the APOE ε2 allele on mortality among the oldest old, but in agreement with our previous findings, we found a 22% increased mortality risk for APOE ε4 carriers. The APOE ε2 allele may be protective on cognitive decline among the oldest old.
机译:一些研究表明,APOEε2等位基因可能对老年人的死亡率和心理健康具有保护作用。我们在实际上已灭绝的丹麦1905年出生队列的1651个成员中调查了APOEε2等位基因对认知功能和死亡率的影响。我们发现,与APOEε3等位基因相比,APOEε2等位基因对死亡率没有保护作用。点估计值表明,随着时间的推移,APOEε2等位基因患者的认知衰退保护作用增强。认知评分并未显着改变各种APOE基因型的死亡风险。我们没有发现APOEε2等位基因对最老的老人有死亡率的保护作用,但是与我们以前的发现一致,我们发现APOEε4携带者的死亡风险增加了22%。 APOEε2等位基因可能对最大的老年人有认知下降的保护作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号