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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >CD4:8 Ratio > 5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study
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CD4:8 Ratio > 5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study

机译：CD4：8比率> 5与主要的天真的T细胞表型和CMV血清阳性的高龄者的身体功能受损有关：BELFRAIL研究的结果

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A subset of older people is at increased risk of hospitalization and dependency. Emerging evidence suggests that immunosenescence reflected by an inverted CD4: 8 ratio and cytomegalovirus (CMV) seropositivity plays an important role in the pathophysiology of functional decline. Nevertheless, the relation between CD4: 8 ratio and functional outcome has rarely been investigated. Here, CD4: 8 ratio and T-cell phenotypes of 235 community-dwelling persons aged >= 81.5 years in the BELFRAIL study and 25 younger persons (mean age 28.5 years) were analyzed using polychromatic flow cytometry. In the elderly persons, 7.2% had an inverted CD4: 8 ratio, which was associated with CMV seropositivity, less naive, and more late-differentiated CD4+ and CD8+ T cells. However, 32.8% had a CD4: 8 ratio >5, a phenotype associated with a higher proportion of naive T cells and absent in young donors. In CMV seropositives, this subgroup had lower proportions of late-differentiated CD4+ and CD8+ T cells and weaker anti-CMV immunoglobulin G reactivity. This novel naive T-cell-dominated phenotype was counterintuitively associated with a higher proportion of those with impaired physical functioning in the very elderly people infected with CMV. This underscores the notion that in very elderly people, not merely CMV infection but also the state of its accompanying immune dysregulation is of crucial importance with regard to physical impairment.
机译：一部分老年人住院和依赖的风险增加。新兴证据表明，CD4：8比例倒置和巨细胞病毒（CMV）血清阳性反映的免疫衰老在功能下降的病理生理学中起着重要作用。然而，很少研究CD4：8比率与功能结局之间的关系。在这里，使用多色流式细胞术分析了BELFRAIL研究中的235位年龄≥81.5岁的社区居民和25位年轻人（平均年龄28.5岁）的CD4：8比率和T细胞表型。在老年人中，有7.2％的CD4：8比率倒置，这与CMV血清反应阳性，天真少和晚期分化的CD4 +和CD8 + T细胞有关。然而，有32.8％的CD4：8比率> 5，这种表型与幼稚T细胞的比例更高有关，并且在年轻供体中不存在。在CMV血清反应阳性患者中，该亚组的晚期分化CD4 +和CD8 + T细胞比例较低，抗CMV免疫球蛋白G反应性较弱。这种新奇的幼稚的T细胞占主导的表型与在感染了CMV的老年人中身体功能受损的人中较高比例的人反直觉相关。这强调了这样的观念，即对于非常年长的人，不仅CMV感染，而且其伴随的免疫失调的状态对于身体损伤也至关重要。

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