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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Socioeconomic and race/ethnic patterns in persistent infection burden among U.S. adults.
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Socioeconomic and race/ethnic patterns in persistent infection burden among U.S. adults.

机译：美国成年人持续感染负担中的社会经济和种族/种族模式。

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BACKGROUND: The pathophysiological mechanisms that underlie health disparities by socioeconomic status and race/ethnicity are poorly understood. Promising new research suggests that the burden of persistent infection may influence adult disease risk and mortality. This article examines how multiple persistent infections cluster within individuals and how this clustering varies by socioeconomic position and race/ethnicity in U.S. adults. METHODS: We analyze data from the National Health and Nutrition Examination Survey III (N = 19,275) for adults aged 17-90 years. The clustering of infections within individuals is studied using tetrachoric correlations. Multiple indicator multiple cause models are used to analyze the infection burden construct as measured by seropositivity to Helicobacter pylori, cytomegalovirus, herpes simplex virus-1, and hepatitis B, focusing on the burden's distribution by socioeconomic position and race/ethnicity. The results are corroborated using ordered logistic regression for acommonly used count index of individual infections. RESULTS: Seroprevalence of individual persistent infections is positively correlated, suggesting common factors related to exposure or susceptibility. Education, income, and race/ethnicity are strong and significant independent predictors of infection burden in U.S. adults in all models. CONCLUSION: The disproportionate burden of persistent infections among disadvantaged groups across all ages may be one biologic pathway by which low socioeconomic position is related to increased rates of morbidity and mortality in the United States.
机译：背景：人们对基于社会经济状况和种族/民族而造成健康差异的病理生理机制了解甚少。有前途的新研究表明，持续感染的负担可能会影响成人疾病的风险和死亡率。本文研究了多种持续性感染如何在个体内聚集以及这种聚集如何随美国成年人的社会经济地位和种族/民族而变化。方法：我们分析了来自美国国家健康与营养检查调查III（N = 19,275）中17-90岁成年人的数据。使用四项相关性研究个体内感染的聚类。通过对幽门螺杆菌，巨细胞病毒，单纯疱疹病毒-1和乙型肝炎的血清阳性率，使用多指标多原因模型来分析感染负担的构建，重点是通过社会经济地位和种族/民族对负担的分布。使用针对单个感染的常用计数指标的有序逻辑回归来证实该结果。结果：个体持续感染的血清阳性率呈正相关，表明与暴露或易感性相关的常见因素。在所有模型中，教育，收入和种族/民族是美国成年人感染负担的有力且重要的独立预测指标。结论：在所有年龄段的弱势群体中，持续感染的负担过大，可能是一种生物学途径，其低社会经济地位与美国发病率和死亡率的增加有关。

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