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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The relationship between cognitive function and physical performance in older women: results from the women's health initiative memory study.
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The relationship between cognitive function and physical performance in older women: results from the women's health initiative memory study.

机译：老年妇女认知功能与身体机能之间的关系：来自妇女健康倡议记忆研究的结果。

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BACKGROUND: Cognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear. METHODS: In the Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline and over a 6-year follow-up period between the Modified Mini-Mental State (3MS) Examination and three physical performance measures (PPMs): gait speed (meters/second), chair stands (number of stands in 15 seconds), and grip strength (kilograms). Using mixed models, we examined the baseline 3MS as predictor of change in PPM, change in the 3MS as predictor of change in PPM, and baseline PPM as predictors of 3MS change. RESULTS: Among 1,793 women (mean age = 70.3 years, 89% white, and mean 3MS score = 95.1), PPM were weakly correlated with 3MS-gait speed: r = .06, p = .02; chair stands: r = .09, p < .001; and grip strength: r = .10, p < .001. Baseline 3MS score was associated with subsequent PPM decline after adjustment for demographics, comorbid conditions, medications, and lifestyle factors. For every SD (4.2 points) higher 3MS score, 0.04 SD (0.04 m/s) less gait speed and 0.05 SD (0.29 kg) less grip strength decline is expected over 6 years (p
机译：背景：认知功能和身体机能是相关的，但是认知和身体衰退的常见顺序仍然不清楚。方法：在妇女健康倡议记忆研究（WHIMS）临床试验中，我们检查了基线状态以及经过修改的小精神状态（3MS）考试与三种身体表现指标（PPM）之间的6年随访期之间的关联：步态速度（米/秒），椅子站立（15秒内站立的次数）和握力（公斤）。使用混合模型，我们检查了基线3MS作为PPM变化的预测因子，基线3MS作为PPM变化的预测因子，基线PPM作为3MS变化的预测因子。结果：在1,793名妇女中（平均年龄= 70.3岁，白人占89％，平均3MS得分= 95.1），PPM与3MS步态速度呈弱相关：r = .06，p = .02;椅子架：r = .09，p <.001;和抓地力：r = .10，p <.001。调整了人口统计学，合并症，药物和生活方式因素后，基线3MS评分与随后的PPM下降有关。每增加6个SD（4.2分），其3MS得分，步态速度将降低0.04 SD（0.04 m / s），并且抓握强度下降的幅度将降低0.05 SD（0.29 kg）（p均= .01）。 3MS和PPM的变化是相关的，特别是与椅子的站立和握力（p均<0.003）有关。基准PPM与随后的3MS更改无关。结论：基线整体认知功能和整体认知功能的变化与身体机能的变化有关，但基线身体机能与该队列中的认知变化无关。这些分析支持以下假设：认知能力下降平均发生在身体机能下降之前或同时发生。

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