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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Molecular adaptations to aerobic exercise training in skeletal muscle of older women.
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Molecular adaptations to aerobic exercise training in skeletal muscle of older women.

机译：对老年女性骨骼肌中有氧运动训练的分子适应。

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BACKGROUND: We have recently shown that 12 weeks of progressive aerobic exercise training improves whole-muscle size and function in older women. The purpose of this investigation was to evaluate molecular markers that may be associated with muscle hypertrophy after aerobic training in aging skeletal muscle. METHODS: Muscle biopsies were obtained before and after 12 weeks of aerobic exercise training on a cycle ergometer in nine older women (70 +/- 2 years) to determine basal levels of messenger RNA and protein content of select myogenic, proteolytic, and mitochondrial factors. RESULTS: The training program increased (p < .05) aerobic capacity 30 +/- 9%, whole-muscle cross-sectional area 11 +/- 2%, and whole-muscle force production 29 +/- 8%. Basal messenger RNA levels of FOXO3A, myostatin, HSP70, and MRF4 were lower (p < .05) after aerobic training. FOXO3A, FOXO3A phosphorylation, and HSP70 protein content were unaltered after training. Mitochondrial protein COX IV was elevated (p < .05) 33 +/- 7% after aerobic training, whereas PGC-1alpha protein content was 20 +/- 5% lower (p < .05). CONCLUSIONS: These data suggest that reductions in FOXO3A and myostatin messenger RNA are potentially associated with exercise-induced muscle hypertrophy. Additionally, it appears that mitochondrial biogenesis can occur with aerobic training in older women independent of increased PGC-1alpha protein. Aerobic exercise training alters molecular factors related to the regulation of skeletal muscle, which supports the beneficial role of aerobic training for improving muscle health in older women.
机译：背景：我们最近显示，进行为期12周的有氧运动训练可以改善老年妇女的全肌肉大小和功能。这项研究的目的是评估在老化的骨骼肌中进行有氧训练后可能与肌肉肥大有关的分子标记。方法：在9名老年妇女（70 +/- 2岁）的自行车测功仪上进行有氧运动训练12周之前和之后，进行肌肉活检，以测定基础信使RNA水平和某些肌原性，蛋白水解性和线粒体因子的蛋白质含量。结果：该训练计划增加了（p <.05）有氧运动能力30 +/- 9％，全肌肉截面积11 +/- 2％，全肌肉力量产生29 +/- 8％。有氧训练后，FOXO3A，肌生长抑制素，HSP70和MRF4的基础信使RNA水平较低（p <.05）。训练后，FOXO3A，FOXO3A磷酸化和HSP70蛋白含量未改变。有氧训练后，线粒体蛋白COX IV升高（p <.05）33 +/- 7％，而PGC-1alpha蛋白含量降低20 +/- 5％（p <.05）。结论：这些数据表明FOXO3A和肌生长抑制素信使RNA的减少可能与运动引起的肌肉肥大有关。此外，似乎有氧运动的老年妇女可以发生线粒体生物发生，而与增加的PGC-1alpha蛋白无关。有氧运动训练会改变与骨骼肌调节有关的分子因素，从而支持有氧训练对改善老年妇女肌肉健康的有益作用。

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