...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli).
【24h】

Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli).

机译：高级糖基化终产物可作为长寿的安塞尔痣鼠（Fukomys anselli）中衰老和长寿的标志。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mole-rat of the genus Fukomys are mammals whose life span is strongly influenced by reproductive status with breeders far outliving nonbreeders. This raises the important question of whether increased longevity of the breeders is reflected in atypical expression of biochemical markers of aging. Here, we measured markers of glycation and advanced glycation end-products formed in insoluble skin collagen of Ansell's mole-rat Fukomys anselli as a function of age and breeding status. Glucosepane, pentosidine, and total advanced glycation end-product content significantly increased with age after correction for breeder status and sex. Unexpectedly, total advanced glycation end-products, glucosepane, and carboxymethyl-lysine (CML) were significantly higher in breeders versus nonbreeders suggesting that breeders have evolved powerful defenses against combined oxidant and carbonyl stress compared with nonbreeders. Most interestingly, when compared with other mammals, pentosidine formation rate was lower in mole-rat compared with other short-lived rodents confirming previous observations of an inverse relationship between longevity and pentosidine formation rates in skin collagen.
机译：Fukomys属的鼠鼠是哺乳动物，其寿命受到繁殖状况的强烈影响，育种者的寿命远远超过非育种者。这就提出了一个重要的问题，即繁殖者寿命的延长是否反映在衰老的生化标志物的非典型表达上。在这里，我们测量了随着年龄和繁殖状态的变化，在安塞尔的s鼠Fukomys anselli的不溶性皮肤胶原蛋白中形成的糖基化和高级糖化终产物的标志物。校正育种者地位和性别后，葡糖窗格糖，戊糖苷和总晚期糖化终产物的含量会随着年龄的增长而显着增加。出乎意料的是，种鸽的总先进糖基化终产物，葡萄糖窗格和羧甲基赖氨酸（CML）显着高于非种鸽，这表明与非种鸽相比，种鸽进化出了强大的防御氧化剂和羰基综合胁迫的能力。最有趣的是，当与其他哺乳动物相比时，戊糖苷的生成速率在摩尔鼠中比其他短寿命的啮齿动物要低，这证实了先前观察到的皮肤胶原中长寿与戊糖苷生成速率之间存在反比关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号