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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Aging in the Glomerulus
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Aging in the Glomerulus

机译：肾小球的衰老

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Kidney function declines with age in the majority of the population. Although very few older people progress to end stage, the consequences of doing so are burdensome for the patient and very expensive for the society. Although some of the observed decline is likely due to changes in the vasculature, much is associated with the development of age-associated glomerulosclerosis. This article will review the well-established structural and functional changes in the glomerulus with age. The role of calorie restriction in modifying age-related pathology will be discussed. The importance of the podocyte as a critical cell in the aging process is considered using animal models and human biopsy material. Newer data on changes in gene expression driven by nuclear factor kappa beta (NFkB) and possible changes in biology in the glomerulus are discussed. The relationship between pathways involved in aging and the decline in kidney function is reviewed. There is speculation on the significance of these changes in relation to normal and pathological aging.
机译：在大多数人口中，肾功能随着年龄的增长而下降。尽管很少有老年人进入末期，但这样做的后果对患者来说是沉重的负担，对社会来说是非常昂贵的。尽管观察到的某些下降可能是由于脉管系统的变化所致，但很多与年龄相关的肾小球硬化的发展有关。本文将回顾肾小球随着年龄的增长而确立的结构和功能的变化。将讨论卡路里限制在改变与年龄有关的病理学中的作用。使用动物模型和人类活检材料考虑了足细胞在衰老过程中作为关键细胞的重要性。讨论了由核因子κβ（NFkB）驱动的基因表达变化的新数据以及肾小球生物学的可能变化。审查了与衰老有关的途径与肾功能下降之间的关系。人们猜测这些变化与正常和病理性衰老有关的重要性。

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