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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
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Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.

机译：骨骼肌线粒体能量与老年人最大的有氧运动能力和步行速度有关。

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Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults.Thirty-seven older adults (mean age 78 years; 21 men and 16 women) completed an aerobic capacity (VO2 peak) test and measurement of preferred walking speed over 400 m. Maximal coupled (State 3; St3) mitochondrial respiration was determined by high-resolution respirometry in saponin-permeabilized myofibers obtained from percutanous biopsies of vastus lateralis (n = 22). Maximal phosphorylation capacity (ATPmax) of vastus lateralis was determined in vivo by (31)P magnetic resonance spectroscopy (n = 30). Quadriceps contractile volume was determined by magnetic resonance imaging. Mitochondrial efficiency (max ATP production/max O2 consumption) was characterized using ATPmax per St3 respiration (ATPmax/St3).In vitro St3 respiration was significantly correlated with in vivo ATPmax (r (2) = .47, p = .004). Total oxidative capacity of the quadriceps (St3*quadriceps contractile volume) was a determinant of VO2 peak (r (2) = .33, p = .006). ATPmax (r (2) = .158, p = .03) and VO2 peak (r (2) = .475, p < .0001) were correlated with preferred walking speed. Inclusion of both ATPmax/St3 and VO2 peak in a multiple linear regression model improved the prediction of preferred walking speed (r (2) = .647, p < .0001), suggesting that mitochondrial efficiency is an important determinant for preferred walking speed.Lower mitochondrial capacity and efficiency were both associated with slower walking speed within a group of older participants with a wide range of function. In addition to aerobic capacity, lower mitochondrial capacity and efficiency likely play roles in slowing gait speed with age.
机译：随着年龄的增长，较低的门诊性能可能与骨骼肌内的氧化能力降低有关。这项研究检查了一组老年人骨骼肌线粒体能力与效率与步行能力之间的关系.37名老年人（平均年龄78岁; 21名男性和16名女性）完成了有氧运动能力（VO2峰值）测试和测量首选步行速度超过400 m。在高分辨率的呼吸测定法中测定最大耦合（状态3; St3）线粒体呼吸作用，该方法由皂苷透化的肌纤维制成，该纤维得自股外侧肌经皮活检（n = 22）。通过（31）P磁共振波谱法（n = 30）在体内确定股外侧肌的最大磷酸化能力（ATPmax）。股四头肌收缩体积通过磁共振成像确定。线粒体效率（最大ATP产生/最大O2消耗）​​使用每个St3呼吸的ATPmax（ATPmax / St3）进行表征。体外St3呼吸与体内ATPmax显着相关（r（2）= .47，p = .004）。股四头肌的总氧化能力（St3 *股四头肌收缩体积）是VO2峰值的决定因素（r（2）= .33，p = .006）。 ATPmax（r（2）= .158，p = .03）和VO2峰值（r（2）= .475，p <.0001）与首选步行速度相关。在多重线性回归模型中同时包含ATPmax / St3和VO2峰可改善对首选步行速度的预测（r（2）= .647，p <.0001），这表明线粒体效率是首选步行速度的重要决定因素。在一组功能广泛的老年参与者中，线粒体能力和效率的降低均与步行速度降低有关。除了有氧运动能力外，线粒体能力和效率的降低还可能随着年龄的增长而降低步态速度。

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