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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Midlife obesity and risk of frailty in old age during a 22-year follow-up in men and women: The mini-Finland follow-up survey
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Midlife obesity and risk of frailty in old age during a 22-year follow-up in men and women: The mini-Finland follow-up survey

机译：男性和女性22年随访中的中年肥胖和年老体弱的风险：小型芬兰随访调查

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Background. Long-term predictors of geriatric syndrome of frailty are unclear. Several obesity-related conditions are associated with frailty. This study examines the predictive role of midlife overweight and obesity on development of frailty more than 22 years of follow-up. Methods. Data are from 1,119 men and women aged 30 or older without frailty at baseline participating in a population-based Mini-Finland Health Examination Survey (1978-1980) with follow-up measurement in 2000-2001. At baseline (1978-1980), body weight and height were measured. At follow-up (2000-2001), the dependent variable prefrailty was defined as the presence of one or two of five frailty indicators (shrinking, weakness, exhaustion, slowness, and low physical activity) and frailty was defined as three or more indicators. Results .The mean age at the baseline was 43.6 (SD 9.7) years, and majority of the participants (95%) were 30-60 years old. Incidence of prefrailty was 5% and frailty 36%. Based on adjusted multinomial logistic regression, persons with overweight (body mass index 25-29.9kg/m2) and obesity (body mass index ≥ 30kg/m 2) at baseline had increased risk of prefrailty (odds ratio 1.45, 95% CI 1.08, 1.96; odds ratio 2.36, 95% CI 1.41, 3.93) and frailty (odds ratio 2.49, 95% CI 1.22, 5.06; odds ratio 5.02, 95% CI 1.89, 13.33) at follow-up in comparison to normal-weight persons after adjusting for age, sex, lifestyle factors and chronic conditions. Conclusions. Development of frailty may start already in midlife, and obesity is one of the underlying causes of frailty.
机译：背景。衰老的老年综合症的长期预测因素尚不清楚。几种与肥胖有关的疾病与虚弱相关。这项研究检查了超过22年随访的中年超重和肥胖对脆弱发展的预测作用。方法。数据来自参加基础人群的迷你芬兰健康检查调查（1978-1980年）的基线时不脆弱的30岁或以上的1119名男性和女性，并在2000-2001年进行了跟踪测量。在基线（1978-1980年）时，测量了体重和身高。在随访（2000-2001年）时，因变量脆弱性被定义为存在五个脆弱性指标中的一两个（收缩，虚弱，疲惫，缓慢和运动量少），而脆弱性被定义为三个或更多指标。结果：基线的平均年龄为43.6（SD 9.7）岁，大多数参与者（95％）为30-60岁。脆弱的发生率为5％，脆弱的发生率为36％。根据调整后的多项Logistic回归，基线时超重（体重指数25-29.9kg / m2）和肥胖（体重指数≥30kg / m 2）的人发生体弱的风险增加（优势比1.45，95％CI 1.08，与体重正常后的人相比，随访时比重为1.96;比值比为2.36、95％CI为1.41、3.93）和虚弱（比值比2.49、95％CI为1.22、5.06;比值5.02、95％CI为1.89、13.33）根据年龄，性别，生活方式因素和慢性病进行调整。结论。脆弱的发展可能已经在中年开始，肥胖是脆弱的根本原因之一。

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