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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline
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Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline

机译：海马亚区对衰老和非神经退行性认知功能减退表现出独特和共同的转录组反应

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Impairment of hippocampal-dependent spatial learning and memory with aging affects a large segment of the aged population. Hippocampal subregions (CA1, CA3, and DG) have been previously reported to express both common and specific morphological, functional, and gene/protein alterations with aging and cognitive decline. To comprehensively assess gene expression with aging and cognitive decline, transcriptomic analysis of CA1, CA3, and DG was conducted using Adult (12M) and Aged (26M) F344xBN rats behaviorally characterized by Morris water maze performance. Each subregion demonstrated a specific pattern of responses with aging and with cognitive performance. The CA1 and CA3 demonstrating the greatest degree of shared gene expression changes. Analysis of the pathways, processes, and regulators of these transcriptomic changes also exhibit a similar pattern of commonalities and differences across subregions. Gene expression changes between Aged cognitively Intact and Aged cognitively Impaired rats often showed an inversion of the changes between Adult and Aged rats. This failure to adapt rather than an exacerbation of the aging phenotype questions a conventional view that cognitive decline is exaggerated aging. These results are a resource for investigators studying cognitive decline and also demonstrate the need to individually examine hippocampal subregions in molecular analyses of aging and cognitive decline.
机译：随着年龄的增长，海马依赖性空间学习和记忆障碍会影响很大一部分老年人口。先前已经报道了海马亚区（CA1，CA3和DG）表达常见和特定的形态，功能以及基因/蛋白质随年龄和认知能力下降的变化。为了全面评估具有衰老和认知下降的基因表达，使用行为特征为莫里斯水迷宫特征的成年（12M）和成年（26M）F344xBN大鼠进行了CA1，CA3和DG的转录组分析。每个次区域都表现出特定的响应方式，与衰老和认知表现有关。 CA1和CA3展示了最大程度的共享基因表达变化。这些转录组变化的途径，过程和调节子的分析也表现出相似的共性和跨亚区域差异的模式。老年认知完好和老年认知障碍大鼠之间的基因表达变化通常显示成年大鼠和老年大鼠之间的变化反转。这种不能适应而不是加剧衰老表型的现象质疑了认知衰弱是夸大衰老的传统观点。这些结果为研究者研究认知能力下降提供了资源，也表明了在衰老和认知能力下降的分子分析中需要单独检查海马亚区。

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