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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Graph theory analysis of functional brain networks and mobility disability in older adults
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Graph theory analysis of functional brain networks and mobility disability in older adults

机译：老年人功能性大脑网络和行动障碍的图论分析

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Background. The brain's structural integrity is associated with mobility function in older adults. Changes in function may be evident earlier than changes in structure and may be more directly related to mobility. Therefore, we assessed whether functional brain networks varied with mobility function in older adults. Methods. Short Physical Performance Battery (SPPB) and resting state functional magnetic resonance imaging were collected on 24 young (mean age = 26.4±5.1) and 48 older (mean age = 72.04±5.1) participants. Older participants were divided into three groups by SPPB score: Low SPPB (score = 7-9), Mid SPPB (score = 10), High SPPB (score = 11-12).Graph theory-based methods were used to characterize and compare brain network organization. Results. Connectivity in the somatomotor cortex distinguished between groups based on SPPB score. The community structure of the somatomotor cortex was significantly less consistent in the Low SPPB group (mean = 0.097±0.05) compared with Young (mean = 0.163±0.09, p =. 03) SPPB group. Striking differences were evident in second-order connections between somatomotor cortex and superior temporal gyrus and insula that reached statistical significance. The Low SPPB group (mean = 140.87±109.30) had a significantly higher number of connections than Young (mean = 45.05±33.79, p =. 0003) or High (mean = 49.61±35.31, p =. 002) SPPB group. Conclusions. Older adults with poorer mobility function exhibited reduced consistency of somatomotor community structure and a greater number of secondary connections with vestibular and multisensory regions of the brain. Further study is needed to fully interpret these effects, but analysis of functional brain networks adds new insights to the contribution of the brain to mobility.
机译：背景。老年人的大脑结构完整性与运动功能有关。功能上的变化可能比结构上的变化更早显现出来，并且可能与移动性更直接相关。因此，我们评估了老年人的功能性大脑网络是否随活动功能而变化。方法。收集了24名年轻（平均年龄= 26.4±5.1）和48个年龄较大（平均年龄= 72.04±5.1）的参与者的短物理性能电池（SPPB）和静息状态功能磁共振成像。较老的参与者按SPPB得分分为三组：低SPPB（得分= 7-9），中SPPB（得分= 10），高SPPB（得分= 11-12）。使用基于图论的方法进行表征和比较脑网络组织。结果。基于SPPB评分在各组之间区分躯体运动皮层的连通性。与年轻的SPPB组（平均值= 0.163±0.09，p =。03）相比，低SPPB组的运动器官皮层的群落结构明显不一致（平均值= 0.097±0.05）。在躯体运动皮层与颞上回和岛之间的二阶联系中，明显的差异是具有统计学意义的。低SPPB组（平均= 140.87±109.30）的连接数明显高于Young（平均= 45.05±33.79，p = 0.003）或高（平均= 49.61±35.31，p = 002）SPPB组。结论。行动功能较弱的老年人表现出降低的躯体运动群落结构一致性，以及与大脑前庭和多感觉区的更多次要联系。需要进一步研究以完全解释这些影响，但是对功能性大脑网络的分析为大脑对活动性的贡献增加了新见解。

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