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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Telomerase Gene (hTERT) and Survival: Results From Two Swedish Cohorts of Older Adults
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Telomerase Gene (hTERT) and Survival: Results From Two Swedish Cohorts of Older Adults

机译：端粒酶基因（hTERT）和生存：两个瑞典老年人群的结果

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摘要

Telomere length has been associated with longevity. As telomere length is partly determined by the human telomerase reverse transcriptase (hTERT), we investigated the association between an hTERT polymorphism located in its promoter region (T-1327/C) and longevity in two cohorts of older adults. Participants from the Kungsholmen project (KP; n = 1,205) and the Swedish National study of Aging and Care in Kungsholmen (SNAC-K; n = 2,764) were followed for an average period of 7.5 years. The main outcomes were hazard ratios (HR) of mortality and median age at death. In both cohorts, mortality was lower in female T/T carriers, aged 75+ years in KP (HR = 0.8, 95% CI: 0.5-0.9) and 78+ years in SNAC-K (HR = 0.6, 95% CI: 0.4-0.8) compared with female C/C carriers. T/T carriers died 1.8-3 years later than the C/C carriers. This effect was not present in men, neither in SNAC-K women aged 60-72 years. The association was not modified by presence of cancer, cardiovascular diseases, number of chronic diseases, or markers of inflammation, and did not interact with APOE genotype or estrogen replacement therapy. The gender-specific increased survival in T/T carriers can be due to a synergistic effect between genetic background and the life-long exposure to endogenous estrogen.
机译：端粒的长度与寿命有关。由于端粒的长度部分由人类端粒酶逆转录酶（hTERT）决定，因此我们研究了位于两个启动子群中位于其启动子区域（T-1327 / C）的hTERT多态性与寿命之间的关联。随访了Kungsholmen项目（KP; n = 1,205）和瑞典国家历史研究（SNAC-K; n = 2,764），平均为7.5年。主要结果是死亡率的危险比（HR）和中位年龄。在这两个队列中，女性T / T携带者的死亡率均较低，KP为75岁以上（HR = 0.8，95％CI：0.5-0.9），而SNAC-K为78岁以上（HR = 0.6，95％CI： 0.4-0.8）与女性C / C携带者相比。 T / T航母比C / C航母晚1.8-3年死亡。男性没有这种作用，年龄在60-72岁的SNAC-K女性也没有。该关联并未因癌症，心血管疾病，慢性疾病的数量或炎症标志物的存在而改变，并且未与APOE基因型或雌激素替代疗法相互作用。 T / T携带者的性别特异性存活率提高可能是由于遗传背景和终生暴露于内源性雌激素之间的协同作用所致。

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