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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Folate, but not homocysteine, predicts the risk of fracture in elderly persons.
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Folate, but not homocysteine, predicts the risk of fracture in elderly persons.

机译：叶酸而非高半胱氨酸可预测老年人骨折的风险。

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BACKGROUND: Recent prospective studies reported that increased plasma homocysteine levels are an independent predictor of osteoporotic fracture in elderly persons. These studies, however, did not take into account folate and vitamin B12, which are the major nutritional determinants of homocysteinemia. METHODS: Incident osteoporotic fractures were assessed in 702 Italian participants aged 65-94 years with a mean follow-up of 4 years (1999/2000-2003/2004). A multivariable logistic regression model was used to study the relation of baseline plasma homocysteine, serum folate, and serum vitamin B12 with risk of fracture. RESULTS: After adjustment for sociodemographic and clinical confounders, the odds ratio (OR) for each increase of 1 standard deviation in log-transformed plasma homocysteine was 1.39 (95% confidence interval [CI], 1.01-1.91), but decreased to 1.22 (95% CI, 0.85-1.74) after further adjustment for serum folate and vitamin B12. The corresponding multivariable-adjusted OR for hyperhomocysteinemia (plasma total homocysteine [tHcy] > 15 micromoL) was 1.58 (95% CI, 0.71-3.53). Participants in the lowest serum folate quartile (< or =9.3 nmol/L) had an increased risk of fracture than did those in higher quartiles (multivariable-adjusted OR = 2.06; 95% CI. 1.02-4.18), but no dose-related protective effect for increasing serum folate levels was found (multivariable-adjusted OR = 0.84 for each increase of 1 standard deviation in log-transformed serum folate, 95% CI, 0.59-1.19). No independent association was found for serum vitamin B12. CONCLUSIONS: Low serum folate is responsible for the association between homocysteine and risk of osteoporotic fracture in elderly persons.
机译：背景：最近的前瞻性研究报道，血浆同型半胱氨酸水平升高是老年人骨质疏松性骨折的独立预测因子。然而，这些研究未考虑叶酸和维生素B12，它们是高半胱氨酸血症的主要营养决定因素。方法：评估了702名年龄在65-94岁的意大利参与者的骨质疏松性骨折，平均随访4年（1999 / 2000-2003 / 2004）。使用多变量logistic回归模型研究基线血浆同型半胱氨酸，血清叶酸和血清维生素B12与骨折风险的关系。结果：在调整了社会人口统计学和临床​​混杂因素后，对数转换后的血浆高半胱氨酸每增加1个标准差，比值比（OR）为1.39（95％置信区间[CI]，1.01-1.91），但降至1.22（ 95％CI，0.85-1.74），然后进一步调整血清叶酸和维生素B12。高同型半胱氨酸血症（血浆总同型半胱氨酸[tHcy]> 15 micromoL）的相应多变量调整后OR为1.58（95％CI，0.71-3.53）。最低叶酸四分位数（<或= 9.3 nmol / L）的参与者比高四分位数（多变量校正OR = 2.06; 95％CI。1.02-4.18）的参与者发生骨折的风险增加，但与剂量无关发现对提高血清叶酸水平具有保护作用（对数转化血清叶酸每增加1个标准差，95％CI，0.59-1.19，多变量调整后的OR = 0.84）。没有发现血清维生素B12的独立关联。结论：血清叶酸水平低与高半胱氨酸与老年人骨质疏松性骨折的风险有关。

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