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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue.
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One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue.

机译：一年的热量限制：对人体组成和腹部脂肪组织的可行性和影响。

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BACKGROUND: Caloric restriction (CR) increases maximal life span in short-lived organisms, and its effects are being explored in nonhuman primates. The objectives of this study were to determine the feasibility of prolonged CR in nonobese adults and to compare the effects of CR- and exercise-induced weight loss on body composition and abdominal adiposity. METHODS: A randomized, controlled trial was conducted with 48 healthy, nonobese women and men, aged 57 +/- 1 (mean +/- standard error [SE]) years, with body mass index 27.3 +/- 0.3 kg/m2. Participants were randomly assigned to a 20% calorically-restricted diet (CR, n = 19), exercise designed to produce a similar energy deficit (EX, n = 19), or a healthy lifestyle control group (HL, n = 10) for 1 year. Assessments included weight, body composition by dual-energy x-ray absorptiometry, abdominal adipose tissue by magnetic resonance imaging, and energy intake by doubly labeled water. RESULTS: The average level of CR achieved by the CR group was 11.5 +/- 2.1%, and the EX group completed 59 +/- 6.7% of their prescribed exercise. Weight changes were greater (p
机译：背景：热量限制（CR）延长了短命生物的最大寿命，并且正在非人类灵长类动物中探索其作用。这项研究的目的是确定在非肥胖成年人中延长CR的可行性，并比较CR和运动引起的体重减轻对身体成分和腹部肥胖的影响。方法：对48名健康，非肥胖的男女进行了一项随机对照试验，年龄57 +/- 1岁（平均+/-标准误差[SE]），体重指数为27.3 +/- 0.3 kg / m2。参与者被随机分配到20％受热量限制的饮食中（CR，n = 19），旨在产生相似能量缺乏的运动（EX，n = 19）或健康的生活方式对照组（HL，n = 10）。 1年。评估包括体重，通过双能X线骨密度仪测量的身体成分，通过磁共振成像测出的腹部脂肪组织以及通过双标记水摄入的能量。结果：CR组的平均CR水平为11.5 +/- 2.1％，EX组完成了规定运动的59 +/- 6.7％。与HL组（-1.3 +/- 0.9 kg）相比，CR（-8.0 +/- 0.9 kg）和EX（-6.4 +/- 0.9）组的体重变化更大（p <或= .0005） ，分别减少了基准重量的10.7％，8.4％和1.7％。 CR和EX组的全身脂肪量以及内脏和皮下腹部脂肪组织显着降低（p <.005），而HL组则没有变化。结论1年的CR可行，但CR的水平低于规定水平。 CR和运动在减轻体重和肥胖方面同样有效。

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